Curriculum vitae
(updated 5/5/2022)

Michael Blaber, Ph.D.

Professor of Biomedical Sciences

College of Medicine

Florida State University

Tallahassee, FL 32306-4300

michael.blaber@med.fsu.edu

Tel: (850) 644-3361

Fax: (850) 644-5781

Education

Date

Degree

Institute

9/85-2/90

Ph.D. Biological Chemistry

UC Irvine

Advisor: Dr. Ralph A. Bradshaw

9/76-6/80

B.A. Biochemistry/Molecular Biology

UC Santa Barbara

Professional Experience

Date

Position

Institute

12/19 - present

Fellow

National Academy of Inventors

10/13 - present

Co-founder

Trefoil Therapeutics, Inc.

4/10 - 6/17

Faculty, Program in Neurosciences

Florida State University

3/09 - 3/14

Invited Research Fellow

Quantum Beam Science Directorate, Japan Atomic Energy Agency

8/07 - present

Professor of Biomed. Sci.

Florida State University

8/05 - 7/07

Assoc. Prof. of Biomed. Sci.

Florida State University

8/00 - 7/05

Assoc. Prof. of Chemistry

Florida State University

9/94 - present

Faculty, Program in Molecular Biophysics

Florida State University

9/94 - 7/00

Assist. Prof. of Chemistry

Florida State University

3/90 - 7/94

Postdoctoral Fellow

HHMI, U Oregon

Advisor: Dr. Brian W. Matthews

9/80 - 8/85

Research Assoc.

Genentech, Inc.

6/80 - 9/80

Research Assist.

Dionex, Inc.

Awards

Date

Award

Description

2020

Outstanding Senior Faculty Educator award

College of Medicine, Florida State University

2018
2018

2018

2016

2015

2013

U.S. Patent 10,022,426

U.S. Patent 10,000,540

U.S. Patent 9,957,310

U.S. Patent 9,469,680 B2

U.S. Patent 8,962,557

U.S. Patent 8,461,111

Fibroblast Growth Factor Mutants Having Improved Functional Half-Life and Methods of their Use, Blaber, M. and Lee, J.

2017

U.S. Patent 9,840,544

Method for Development of a Peptide Building Block Useful for de novo Protein Design, Blaber, M. and Lee, J.

2017

U.S. Patent 61/149,823

Fibroblast Growth Factor (FGF) 1 with Mutation in the Heparin Binding Domain and Methods of Use to Reduce Blood Glucose, Evans, R., Atkins, A., Downes, M., Yu, R., Blaber, M and Xia, X. (pend.)

2017

U.S. Patent 9,783,587

Synthetic Foldable Proteins Generated from Peptide Segments of Folding Nuclei of Reference Proteins, Blaber, M. and Longo, L.M.

2017

U.S. Patent 9,717,217

Small Animal Restraint Harness or Jacket, Blaber, M. and Blaber, S.

2016

Inclusion in "Protein Evolution and Design" special issue

Evolution of a Protein Folding Nucleus, Xia, X., Longo, L.M., Sutherland, M.A. and Blaber, M., Protein Science 25, 1227-1240 PMID: 26610273

2015

Journal Cover Article

Structural basis for acceptor-substrate recognition of UDP-glucose: anthocyanidin 3-O-glucosyltransferase from Clitoria ternatea, Hiromoto, T., Honjo, E., Tamada, T., Noda, N., Kazuma, K., Suzuki, M., Blaber, M. and Kuroki, R., Protein Science 24, 395-407 PMID: 25556637

2015

Inclusion in "Two Decades of Excellence in Biotechnology" special issue

Mutation Choice to Eliminate Buried Free Cysteines in Protein Therapeutics, Xia, X., Longo, L.M. and Blaber, M. J. Pharm. Sci. 104, 566–576 PMID: 25312595

2015

FSU Art in STEM Award

X-ray Crystallography Structure of "Protofoil" a Designed Symmetric Protein (Connie Tenorio and Liam Longo)

2014

U.S. Patent 13/963,023

Design of FGF-1 Mutants to Effectively Eliminate Reactive Cysteine Residues, Blaber, M. and Xia, X. (pend.)

2014

Journal Cover Article

Symmetric Protein Architecture in Protein Design: Top-Down Symmetric Deconstruction, Longo, L. and Blaber, M., Protein Design, Meth. Molec. Biol. 1216:161-82 PMID: 25213415

2013

Licensed IP

Trefoil Therapeutics, Inc., Mutants of Fibroblast Growth Factor-1

2013

Licensed IP

Lomir Biomedical Inc., Small Animal Restraint Harness

2013

Outstanding Senior Faculty Researcher Award

College of Medicine, Florida State University

2013

Kasha Award for Best Publication in Molecular Biophysics Faculty of 1000 Citation

Simplified Protein Design Biased for Pre-Biotic Amino Acids Yields a Foldable, Halophilic Protein, Longo, L., Lee, J. and Blaber, M., Proc. Natl. Acad. Sci. U S A.  110, 2135-2139 PMID: 23341608

2013

Poster Award

Life Sciences Symposium, Florida State University

2012

Protein Science Best Paper Award

Experimental Support for the Foldability-Function Tradeoff Hypothesis:  Segregation of the Folding Nucleus and Functional Regions in FGF-1, Longo, L., Lee, J. and Blaber, M., Prot. Sci. 21, 1911-1920 PMID: 23047594

2012

2012

2012

2010

U.S. Patent 8,119,776

U.S. Patent 8,153,770

U.S. Patent 8,153,771

U.S. Patent 7,659,379

Mutants of Human Fibroblast Growth Factor Having Increased Stability and/or Mitogenic Potency, Blaber, M. and Dubey, V.K.

2012

Journal Cover Article

Structure and Function of d1-Tetrahydrocannabinolic Acid (THCA) Synthase, the Enzyme Controlling the Psychoactivity of Cannabis sativa, Shoyama, Y., Tamada, T., Kurihara, K., Takeuchi, A., Taura, F., Arai, S., Blaber, M., Shoyama, Y., Morimoto, S. and Kuroki, R., J. Mol. Biol. 423, 96-105 PMID: 22766313

2012

Innovator Award

Florida State University

2011

Journal Cover Article Faculty of 1000 Citation

A polypeptide "building block" for the ß-trefoil fold identified by "top-down symmetric deconstruction", Lee, J., Blaber, S., Dubey, V. and Blaber, M., J. Mol. Biol. 407, 744–763 PMID: 21315087

2011

Faculty of 1000 Citation

Experimental support for the evolution of symmetric protein architecture from a simple peptide motif, Lee, J. and Blaber, M., Proc. Natl. Acad. Sci. 108, 126-130 PMID: 21173271

2010

U.S. Patent 7,754,216

Method of Treating Multiple Sclerosis with Anti-K6 Antibody, Scarisbrick, I.A., Blaber, S.I., Blaber, M. and Rodriguez, M.

2010

U.S. Patent 7,790,682

Engineered Human Acidic Fibroblast Growth Factors and Associated Methods, Blaber, M. and Brych, S.

2010

Innovator Award

Florida State University

2010

2010

2009

U.S. Patent 7,776,825

U.S. Patent 7,696,171

U.S. Patent 7,595,296

Mutant Polypeptides of Fibroblast Growth Factor 1, Blaber, M. and Dubey, V.K.

2009

E.K. Frey-E. Werle Commemorative Gold Medal

KLK peptidases: Structural biology, enzymology and activation profiles

2008

European Patent 1,513,553 B1

Methods and Materials for Treating and Diagnosing Kallikrein-6 Related Inflammatory Conditions, Scarisbrick, I.A., Blaber, S.I. and Blaber, M.

2007

Outstanding Senior Faculty Researcher Award

College of Medicine, Florida State University

2007

Innovator Award

Florida State University

2006

Innovator Award

Florida State University

2005

Faculty of 1000 Citation

Sequence-Swapping does not Result in Conformation-Swapping for the β4/β5 and β8/β9 β-Hairpin Turns in Human Acidic Fibroblast Growth Factor, Kim, J., Lee, J., Brych, S.R., Logan, T.M. and Blaber, M., Prot. Sci. 14, 351-359 PMID: 15632285

2005

Tenure

College of Medicine, Florida State University

2004

Journal Cover Article

An Atomic Resolution Structure for Human Fibroblast Growth Factor-1, Bernett, M.J., Somasundaram, T. and Blaber, M. Proteins: Structure, Function and Bioinformatics 57, 626-634 PMID: 15382229

2004

Innovator Award

Florida State University

2003

Journal Cover Article

Accommodation of a highly symmetric core within a symmetric protein superfold, Brych, S.R., Kim, J., Logan, T.M. and Blaber, M., Protein Science 12, 2704 - 2718 PMID: 14627732

2002

Faculty Ranking #1

Department of Chemistry, Florida State University

2000

Tenure

College of Arts and Sciences, Florida State University

1999

University Teaching Award

Undergraduate General Chemistry, Florida State University

1995

First Year Assistant Professor Award

Florida State University

1993

U.S. Patent 5,219,569

Protease Resistant Urokinase, Blaber, M., Heyneker, H.L. and Vehar, G.A.

1993

Journal Cover Article

Synthetic Chimeras of Mouse Growth Factor-associated Glandular Kallikreins. I. Kinetic Properties, Blaber, M., Isackson, P.J., Burnier, J.P., Marsters, J.C.Jr. and Bradshaw, R.A. Prot. Sci. 2, 1210-1219 PMID: 8401206

1990

N.I.H. Postdoctoral Fellowship GM13709-01

HHMI, University of Oregon

1989

Earl C. Anthony Dissertation Fellowship

U.C. Irvine

1986

N.I.H. Predoctoral Fellowship GM07134-11

U.C. Irvine

Teaching

Date

Course

2020 F

PAS 5025 Fundamentals of Clinical Physiology

3 Lectures

2020 F

PAS 5045 Integrated Clinical Sciences

4 Lectures

2020 F

PAS 5071 Clinical Pharmacology I

12 Lectures

2019-2020 Su

GMS 6001 Biophysics

Course Director, 20 Lectures

2019-2020 Su

PAS 5029 Systemic Physiology II

3 Lectures

2019 F

BMS 6040 Gastrointestinal System

Grader

2019 F

PAS 5025 Fundamentals of Clinical Physiology

3 Lectures

2019 F

PAS 5045 Integrated Clinical Sciences

4 Lectures

2019 F

PAS 5071 Clinical Pharmacology I

12 Lectures

2019-2020 Sp

BMS 6044 Hematologic System

Grader

2018 F

PAS 5025 Fundamentals of Clinical Physiology

3 Lectures

2018 F

PAS 5045 Integrated Clinical Sciences

4 Lectures

2018 F

PAS 5071 Clinical Pharmacology I

12 Lectures

2018 Su

GMS 6001 Special Topics in Presentation Skills

1 Lecture

2018 Su

PAS 5029 Systemic Physiology II

3 Lectures

2018 Sp

BMS 6043 Endocrine and Renal-Urinary Systems

Grader

2018 Sp

BMS 6042 Cardiovascular and Pulmonary Systems

Grader

2008 - 2020 Sp

BMS 5525 Bioregulation

2 Lectures

2017 F

BMS 6047 Musculoskeletal and Integumentary Systems

Grader

2017 F

BMS 6046C Neuroscience: CNS and Behavior

Grader

2017 F

PAS 5025 Fundamentals of Clinical Physiology

3 Lectures

2017 F

PAS 5045 Integrated Clinical Sciences

4 Lectures

2017 F

PAS 5071 Clinical Pharmacology I

12 Lectures

2017 Su

GMS 6001 Special Topics in Biomedical Sciences

2 Lectures

2014 - 2022 Sp

IHS 4120 Frontiers in Medicine

Course Director

2005 - 2009 F, 2010 Sp, 2011 F

BMS 6601 General Pathology & Immunology

Small group facilitation

2009 - 2010 Sp, 2011 F

BMS 6401 Medical Pharmacology

Small group facilitation

2009 F

BMS 6301 General Medical Microbiology

Small group facilitation

2007 Sp

BMS 6204 Medical Biochemistry

Course Co-Director

2006 - 2009 Sp

BMS 6520 Systemic Physiology

Small group facilitation

2006 - 2007 Sp

BMS 6204 Medical Biochemistry

Small group facilitation

2006 Sp

BMS 6001 Epigenetics

1 Lecture

2005 - 2006 F

BMS 6110C Clinical Microanatomy

Small group facilitation

2004 Sp

BCH4053L Biochemistry Lab

Development of web-based lectures:

http://mikeblaber.org/oldwine/BCH4053l/bch4053l.htm

2002 - 2004 Sp

BMS 6204 Medical Biochemistry

7 Lectures

2001 - 2003 F

BCH4053 Biochemistry I

Course Director

2001

BCH4053 Biochemistry I

Development of web-based lectures:

http://mikeblaber.org/oldwine/BCH4053/bch4053.htm

2000 - 2003 Sp

CHM1046 General Chemistry II

Course Director

2000

CHM1046 General Chemistry II

Development of web-based lectures:

http://mikeblaber.org/oldwine/chm1046/chm1046.htm

1999 Su

CHM1045 General Chemistry I (distance learning)

Course Director

1999

CHM1045 General Chemistry I

Development of web-based lectures:

http://mikeblaber.org/oldwine/chm1045/chm1045.htm

1996, 1998 - 2000 F

CHM 1045 General Chemistry I

Course Director

1996

BCH5425 Molecular Biology and Biotechnology

Development of web-based lectures:

http://mikeblaber.org/oldwine/bch5425/bch5425.htm

1996 - 1999 Sp

BCH 5425 Molecular Biology and Biotechnology

Course Director

1995 Sp

BCH5887 Protein Structure and Stability

Course Director

Postdoctoral Fellows Trained

Date

Name

Program/Awards

2021

Dr. Connie Tenorio

Biomedical Sciences

2009 - 2010

Dr. Hyesook Yoon

Biomedical Sciences

2013 Third Place Platform Presentation Award, 5th International Symposium on Kallikreins and Kallikrein Related Peptidases

2007 - 2010

Dr. Jihun Lee

Biomedical Sciences

2010 Outstanding Achievement as a Postdoctoral Scholar Award

Faculty of 1000 Citation: Proc. Natl. Acad. Sci. 108, 126-130 (2011)

Faculty of 1000 Citation: J. Mol. Biol. 407, 744–763 (2011)

U.S. Patent 8,461,111; 8,962,557; 9,469,680 B2; 13/044,723 (pend.)

2007 - 2008

Dr. Akshaya Meher

Biomedical Sciences

2004 - 2006

Dr. Vikash K. Dubey

Molecular Biophysics

U.S. Patent 7,595,296; 7,659,379; 7,696,171; 7,776,825; 8,119,776; 8,153,770; 8,153,771

2004 - 2005

Dr. Jhimli Dasgupta

Molecular Biophysics

1999 - 2000

Dr. Steven Whitten

Molecular Biophysics

1998

Dr. Ramesh Badisa

Molecular Biophysics

1997 - 1999

Dr. Sumit Khurana

Molecular Biophysics

Graduate Students - Major Professor

Date

Name

Degree

Thesis Title/Awards

2014 - 2020

Connie A. Tenorio-Zambrano

Ph.D. Biomedical Sciences

Folding Nucleus Perturbation and Alternative Folding Pathways

2020 Bryan W. Robinson Endowment Award

2018 Hurt Leadership Award

2016 Randolph L. Rill Outstanding Graduate Student Award

2011 - 2015

Xue Xia

Ph.D. Biomedical Sciences

Engineering Fibroblast Growth Factor-1 (FGF-1) as a Human Therapeutic

U.S. Patent 61/149,823 (pend.); 13/963,023 (pend.);

2010 - 2014

Liam M. Longo

Ph.D. Molecular Biophysics

Symmetry and Simplicity in Protein Evolution and Design

Faculty of 1000 Citation: Proc. Natl. Acad. Sci. U S A. 110, 2135-2139 (2013)

2013 Kasha Award for Outstanding Publication

2013 2nd Place Poster Award, 4th Annual FSU Life Sciences Symposium

2012 Protein Society Award for Outstanding Publication

U.S. Patent 14/707,691 (pend.)

2011 - 2013

Helen Phipps

Ph.D. Biomedical Sciences

Impact of Traumatic Brain Injury on Kallikrein-related Peptidase 6

2010 - 2011

Sara Jackson

M.S. Biomedical Science

 

2005 - 2010

Cristina Russo

Ph.D. Molecular Biophysics

Salt-dependence of protein-DNA binding: insights into protein electrostatics and redesign

(Co-advisor: Dr. Marcia Fenley, Physics)

2005 - 2008

Hyesook Yoon

Ph.D. Chemistry

Activation profiles and regulatory cascades of the Human Kallikrein-related peptidases

2005 - 2006

Nikki Held

M.S. Chemistry

 

2003 - 2007

Jihun Lee

Ph.D. Chemistry

Characterization of the Effects of b-Turn Sequence on Protein Stability, Folding Kinetics, Functionality and Turn Structure

2002 - 2006

Gurunathan Laxmikanthan

Ph.D. Chemistry

An Insight into the Structure, Function and Activation Cascades of the Classical Human Kallikreins

AHA Predoctoral Fellowship

2002 - 2005

Jocelyn Dudley

M.S. Chemistry

NSF GK-12 Fellowship

2001-2004

Matthew J. Bernett

Ph.D. Chemistry

High-Resolution Structures of the Proteins Human Kallikrein 6 and Human Fibroblast Growth Factor-1: Structure and Function Relationships

1999 - 2004

Stephen R. Brych

Ph.D. Chemistry

A Redesigned Hydrophobic Core of a Symmetric Protein Superfold with Increased Primary Structure Symmetry

NSF Fellowship

U.S. Patent 7,790,682

1999 - 2003

Jaewon Kim

Ph.D. Chemistry

Structure and Biophysical Characterization of b-turn of Human Acidic Fibroblast Growth Factor

Faculty of 1000 Citation: Prot. Sci. 14, 351-359 (2005)

1998 - 2002

Gulsah Sanli

Ph.D. Chemistry

Expression and Structural Characterization of 2,5-Diketo-D-Gluconic Acid Reductase : A Commercially Important Enzyme for Biosynthesis of Vitamin C

1998 - 1999; 2002

Heidi Wenger

M.S. Chemistry

 

1996 - 2000

Frank J. Culajay

M.S. Biological Science

Thermodynamic Characterization of Mutations of Human Acidic Fibroblast Growth Factor

1995 - 2002

Daniel Adamek

Ph.D. Molecular Biophysics

Characterization of the Hydrophobic Cavity of Interleukin 1-Beta

(Co-advisor: Dr. Donald L.D. Caspar, Biological Science)

1994 - 1996

Aleksandar Popovic

M.S. Chemistry

 

1994 - 1996

Elodie Lang

M.S. Chemistry

 

Medical Student Research Supervisor

Date

Name

Project

2020 - 2021

Joseph Brandon Parker

Folding nucleus perturbation mutations in a de novo designed symmetric β-trefoil protein

2018

Alli Blumstein

Evaluating sex related differences in dermal wound healing in an aged mouse model using engineered FGF-1

2017

Bhavi Patel

Age- and Sex-related Dermal Healing in the BALB/cByJ Mouse

2013

Joseph P. Babcock

Accelerated Healing due to Engineered “Second-Generation” Fibroblast Growth Factor-1

Graduate Students - Thesis Committee

Date

Name

Program

2020 - present

Alexander Piwko

Chemistry & Biochemistry

2020 - present

Ruizhi Peng

Molecular Biophysics

2019 - present

Kirsten Tucker

Chemistry & Biochemistry

2019 - present

Chaowei Hu

Chemistry & Biochemistry

2019 - present

Jennifer Warnock

Biomedical Sciences

2018 - present

Dolly Al Koborssy

Neuroscience

2018 - present

Marisa Tillery

Biomedical Sciences

2018 - present

Christopher Evoniuk

Chemistry & Biochemistry

2018 - present

Yuan Lin

Chemistry & Biochemistry

2017 - 2021

Randi Reed

Biomedical Sciences

2017 - 2021

Anuska Das

Molecular Biophysics

2017 - 2021

Jamie Johnston

Biomedical Sciences

2016 - present

Weijia Leng

Chemistry & Biochemistry

2015 - present

Alan Shomo

Chemistry & Biochemistry

2015 - 2017

Anthony Banks

Molecular Biophysics

2014 - 2019

Joseph Pennington

Molecular Biophysics

2014 - 2019

Archishman Ghosh

Molecular Biophysics

2013 - 2015

Emily Lee

Biological Science

2012 - 2013

Erick Aitchison

Molecular Biophysics

2012 - 2016

Yeqing Tao

Chemistry & Biochemistry

2011 - 2015

Anna Kozlova Wright

Molecular Biophysics

2011 - 2015

Miles Bradshaw

Biological Science

2010 - 2016

Xue Wang

Chemistry & Biochemistry

2010 - 2014

Joey Bowler

Chemistry & Biochemistry

2010 - 2012

Yuan Mao

Chemistry & Biochemistry

2010 - 2013

Qian Zhang

Chemistry & Biochemistry

2010 - 2013

Santosh Valeja

Chemistry & Biochemistry

2010 - 2011

Ian Walton

Chemistry & Biochemistry

2009 - 2013

Anna Lomasney

Chemistry & Biochemistry

2009

Van Quach

Chemistry & Biochemistry

2009 - 2011

Robert Harris

Molecular Biophysics

2009 - 2010

Robert Demont

Chemistry & Biochemistry

2008 - 2011

Larry Walker

Chemistry & Biochemistry

2008 - 2010

Xu Wang

Chemistry & Biochemistry

2008 - 2010

Casey O'Brien

Chemistry & Biochemistry

2007 - 2011

Bodhand Dhole

Biological Science

2007 - 2011

Deepa Salagala

Molecular Biophysics

2007 - 2011

Qiyu Zhu

Chemistry & Biochemistry

2006 - 2009

Jyotica Batra

Physics

2006 - 2009

Alex Chew

Molecular Biophysics

2006 - 2007

Richard Chi

Biological Science

2006 - 2007

Lee Miller

Chemistry & Biochemistry

2006 - 2007

Boris Breiner

Chemistry & Biochemistry

2005 - 2011

Karen Alvarez-Delfin

Biological Science

2005 - 2008

Pallavi Tawdi

Biological Science

2005 - 2008

Shenping Wu

Molecular Biophysics

2005 - 2007

Heather Ongley

Chemistry and Biochemistry

2005 - 2007

Ramzi Alsallaq

Molecular Biophysics

2004 - 2008

Zhang, Xiaojun

Biological Science

2004 - 2006

Mioara Larion

Chemistry and Biochemistry

2004 - 2006

Sumiko Takahashi

Chemistry and Biochemistry

2003 - 2007

Sri Oruganti

Chemistry and Biochemistry

2003 - 2006

Maria Semavina

Molecular Biophysics

2003 - 2007

Ilker Sen

Molecular Biophysics

2003 - 2007

Sunjin Jo

Chemistry and Biochemistry

2003 - 2005

Geoffrey C. Klein

Chemistry and Biochemistry

2002 - 2007

Yun Kang

Biological Science

2001 - 2007

Weishu Bu

Molecular Biophysics

2000 - 2003

Mohammad Yousef

Molecular Biophysics

1999 - 2000

Laura Mertz

Chemistry

1998 - 2004

James Gattis

Chemistry

1998 - 2002

Pamela Twigg

Molecular Biophysics

1998 - 2000

Maria Elena Vasquez

Mathematics

1998 - 1999

Anne Stone

Molecular Biophysics

1998 - 1999

Jeffery Haber

Molecular Biophysics

1997 - 2001

Alla Korpanova

Molecular Biophysics

1996 - 2001

Scott Olenych

Biological Science

1996 - 2001

Ana deCarvalho

Biological Science

1996 - 2001

Virginia A. Gottschalk

Biological Science

1996 - 2001

Eric Fontano

Molecular Biophysics

1996 - 1999

Brian Patterson

Chemistry

1996 - 1998

Ken Mann

Biological Science

1996 - 1997

Li Zhang

Chemistry

1996 - 1997

Paul Schmidt

Chemistry

1996 - 1996

John H. Evans IV

Biological Science

1995 - 1997

Delbert D. Bauzon

Chemistry

1994 - 1997

Zivana Tezak

Biological Science

Undergraduate Students

Date

Name

Program

2020 Sp

Austin Krauza

Directed Independent Studies

2020 Sp

Sydney Rader

Volunteer

2020 Sp

Destiny Wiggins

Volunteer

2019 Sp - 2019 Su

Hannah Cohen

Directed Independent Studies

2019 Sp - 2019 Su

Lauren McGarry

Directed Independent Studies

2018 F

Madelyn Dotson

Honors Thesis Comittee

2018 F

Zoe Parrales

Work/Study Lab Assistant

2018 F - 2019 Su

Daena Senatus

Work/Study Lab Assistant

2018 Sp

Andrew Huh

Volunteer

2018 Sp

Lauren Passino

Volunteer

2018 Sp

Haley Peterson

Volunteer

2017 F

Diana Lacatusu

Honor Thesis

2017 Su - 2019 Su

Brooke Hagerott

Directed Independent Studies

2017 Su

Jake Golden

Directed Independent Studies

2017 Su

Brett Powell

Honors Thesis

2016 F - 2017 Sp

Justin Bartell

Directed Independent Studies

2016 F

Nicole Grubb

Directed Independent Studies

2016 Su

Luis Adrian Tenorio

High School Internship

2016 Sp

Rolando Gerena

Directed Independent Studies

2016 Sp

Rachel Drummey

Honors Thesis Committee

2015 F - 2017 Sp

2017 Su - 2018 Sp

2020 Sp

Brandon Parker

Directed Independent Studies

Honors Thesis

2015 Sp

2015 Su - 2015 F

Mason Sutherland

Directed Independent Studies

Honors Thesis

Evolution of a Protein Folding Nucleus, Xia, X., Longo, L.M., Sutherland, M.A. and Blaber, M., Prot. Sci. 25, 1227-1240 (2016)

2014 Su - 2015 Sp

Andres Crucet-Choi

Directed Independent Studies

2014 Sp - 2015 F

Anneliese Morrison

Honors Thesis Committee

2013 Su

Ashley Pitt

Honors Thesis Committee

2013 Sp

Michelle Krotec

Directed Independent Studies

2012 Su - 2012 F

Gabriela Balicas

Directed Independent Studies

2012 Sp

Connie A. Tenorio-Zambrano

Directed Independent Studies

2011 Sp - 2011 F

Joseph Babcock

Directed Independent Studies

2010 F - 2011 Sp

Jonathan Truong

Directed Independent Studies

2010 Sp - 2010 F

Michael Binner

Directed Independent Studies

2009 Su

Elise Gunzburger

Research Assistant

2008 Su - 2010 Sp

Winston Lee

Research Assistant

2008 Su - 2008 F

Annalise Smith

Directed Independent Studies

2008 Sp - 2009 Sp

Eric Aspinwall

Directed Independent Studies

X-ray Structure and Biophysical Properties of Rabbit Fibroblast Growth Factor-1, Lee, J., Blaber, S.I., Irsigler, A., Aspinwall, E. and Blaber, M., Acta Cryst. F. 65, 1097-1104 (2009)

2007 F - 2009 F

Miles Bradshaw

Honors Thesis Committee

2007 F

2008 Sp - 2008 F

Farhan Abdul Rashid

Work study

Directed Independent Studies

2007 F - 2008 Sp

Marni Becker

Directed Independent Studies

2007 F

Collin Tully

Volunteer Research Assistant

2006 Su

Chris Carr

Directed Independent Studies

2006 Sp

Sharmeel Maraj

Directed Independent Studies

2006 Sp

Jazmin Overton

Directed Independent Studies

2005 F - 2007 F

Benjamin Katz

Honors Thesis Committee

2005 F - 2009 Sp

Liam Longo

Directed Independent Studies

American Cancer Society Fisher Undergraduate Fellowship (2008)

FSU Undergraduate Research and Creative Endeavors (URACE) Award (2008)

A Logical OR Redundancy within the Asx-Pro-Asx-Gly Type I β-turn Motif, Lee, J., Dubey, V.K., Longo, L.M. and Blaber, M. J. Mol. Biol. 377, 1251-1264 (2008)

2005 Sp - 2006 Sp

Mei-Ling Shotts

Directed Independent Studies

2005 Sp

2005 Su - 2006 Sp

Lauren Seabrooks

Directed Independent Studies

Hughes Fellow

2005 Sp

Laura Griffith

Directed Independent Studies

2004 F - 2006 Sp

Aaron Rodriguez

Directed Independent Studies

Activation Profiles and Regulatory Cascades of the Human Kallikrein-related Peptidases, Yoon, H., Laxmikanthan, G., Lee, J., Blaber, S.I., Rodriguez, A., Kogot, J.M., Scarisbrick. I.A. and Blaber, M., J. Biol. Chem. 282, 31852-31864 (2007)

2004 F

Shadee Thomas Lake

Directed Independent Studies

2004 Su - 2005 Sp

John Jacob

Hughes Fellow

2003 F - 2004 Sp

2004 Su - 2005 Sp

Michael Miller

Directed Independent Studies

Hughes Fellow

2003 Su - 2004 Sp

Jamie Woodcock

Directed Independent Studies

2003 Su - 2004 Sp

Stephen Viel

Directed Independent Studies

2002 F - 2003 Sp

Joanna Balsamo

Directed Independent Studies

2001 F - 2003 Sp

Nicholas Frost

Directed Independent Studies

American Cancer Society Fisher Undergraduate Fellowship (2002)

2001 Su - 2002 Su

Scott Agbuya

Directed Independent Studies

2001 Su - 2002 Su

Ginger Spielmann

Directed Independent Studies

2001 Su - 2002 F

Jenni Chikar

Directed Independent Studies

2001 Su - 2002 F

Kim Pause

Directed Independent Studies

2000 F

Stephen Klusza

Honors Thesis Committee

2000 F

Colleen Mulvey

Honors Thesis Committee

2000 F

Michele Blanco

Directed Independent Studies

2000 Su

William Paneral

Directed Independent Studies

2000 Sp

Amy Peterson

Honors Thesis Committee

2000 Sp

Binitie Odian

Honors Thesis Committee

1999 F

Cherra Pumphrey

Directed Independent Studies

1999 F - 2000 Sp

John Davis

Directed Independent Studies

Protein Thermal Characterization and Parameter Analysis: A Rapid, Flexible Analysis on the Windows Platform, Grek, S., Davis, J.K., and Blaber, M. Thirty-Second Southeastern Symposium on System Theory Proceedings, Roberts, R.G. and Simons, F.O., Jr., Eds. (2000) pp. 41-45

An Efficient, Flexible-Model Program for the Analysis of Differential Scanning Calorimetry Data, Grek, S., Davis, J. and Blaber, M. Prot. Pep. Lett. 6, 429-436 (2001)

2000 Sp

Sarah Brockway

Honors Thesis Committee

1999 Sp

Nathan Noble

Directed Independent Studies

1998 F - 1999 Sp

David Kennedy

Directed Independent Studies

1998 Sp - 1999 Sp

Kesha Williams

Directed Independent Studies

NSF Undergraduate Fellowship (1998)

1997 Sp

Jaime Schiller

Directed Independent Studies

1997 Sp

Emily Earp

Directed Independent Studies

1997 Sp - 2000 Su

Sasha Grek

Directed Independent Studies

American Cancer Society Fisher Fellowship (1997)

Florida Space Grant Consortium Fellowship (1998)

American Cancer Society Fisher Fellowship (1999)

Caffrey Fellowship (1999)

An Efficient, Flexible-Model Program for the Analysis of Differential Scanning Calorimetry Data, Grek, S., Davis, J. and Blaber, M. Prot. Pep. Lett. 6, 429-436 (2001)

Protein Thermal Characterization and Parameter Analysis: A Rapid, Flexible Analysis on the Windows Platform, Grek, S., Davis, J.K., and Blaber, M. Thirty-Second Southeastern Symposium on System Theory Proceedings, Roberts, R.G. and Simons, F.O., Jr., Eds. (2000) pp. 41-45

1996 F

Jorge Hernandez

Directed Independent Studies

1996 Su

Stephanie Dillon

Directed Independent Studies

1996 Sp

William Greenleaf

Honors Thesis

1995 Sp - 1996 Sp

Cinthia Hahm

Directed Independent Studies

1995 Su - 1995 F

Daniel Adamek

Directed Independent Studies

1995 Sp

Amanda Childers

Honors Thesis

1995 Sp

Nicole Alavi

Honors Thesis

Service

Date

Position

Organization

Editorial and Advisory Boards

1/2014 - present

Editorial Advisory Board Member

Journal of Pharmaceutical Sciences

11/2013 - present

Cofounder, Scientific Advisory Board Member

Trefoil Therapeutics, Inc.

8/2010 - present

Editorial Board Member

Archives of Biochemistry and Biophysics

7/2010 - 6/2013

Editorial Board Member

Research and Reports in Biology

8/2008 - present

Founding Editor/Editor for Protein Section

Journal of Proteins and Proteomics

12/2008 - 12/2009

Cofounder, Scientific Advisory Board Member

Zign Therapeutics, LLC.

1/2008 – 12/2008

Scientific Advisory Board Member

CardioVascular BioTherapeutics, Inc.

1/2006 - 12/2008

1/2003 - 12/2005

Editorial Advisory Board Member

Protein Science

6/2001 - 8/2006

Editorial Board Member

Molecular and Cellular Proteomics

Peer Review

2018

Czech Science Foundation, EXPRO Division, grant review

2015

Air Force Office of Scientific Research, Air Force Defense Research Sciences Program

8/2013

National Science Foundation, Molecular Biochemistry Ad hoc.

2/2008

N.I.H. Macromolecular Structure and Function (MSFC) Study Section Ad hoc.

8/2005

National Science Foundation, Integrative Organismal Biology Panel Ad hoc.

10/2004 - 4/2008

National Science Foundation, Molecular Biochemistry Panel

10/2004 - 10/2006

American Heart Association, Cell Function & Metabolism

9/2004

National Science Foundation, Molecular Biochemistry Ad hoc.

8/2004

National Science Foundation, Molecular Biophysics Ad hoc.

6/2004

N.I.H. High End Shared Instrumentation ZRG1 BPC-D 30 1

3/2004

American Heart Association, Southern and Ohio Valley Research Consortium, Committee 3A

2001

NASA (NRA 00-HEDS-03 Cellular and Macromolecular Biotechnology), Structural Biology Panel

1996 - 2003

American Cancer Society, Florida Division

1996, 2000, 2005

Petroleum Research Foundation Ad hoc.

Organizer/Officer

2012

International Advisory Board, International Interdisciplinary Science Conference (I-ISC, 2012) on Protein Folding and Disease, New Delhi, India

2012

Session Chair, Tracks 1-9, OMICS Group International Conference on Regenerative & Functional Medicine, San Antonio

2011

Chair, International Scientific Advisory Board, 4th International Symposium on Kallikreins and Kallikrein-related Peptidases

2011 - 2013

Chair, Organizing Committee, Life Sciences Symposium, Florida State University

2009

International Scientific Advisory Board, 3nd International Symposium on Kallikreins and Kallikrein-related Peptidases

2007

Scientific Organization Committee, 2nd International Symposium on Kallikreins and Kallikrein-related Peptidases

2005

Immediate Past Chair, American Chemical Society, Florida Section

2004

Chair, American Chemical Society, Florida Section

2003 - 2005

James R. Fisher Fellowship Committee, American Cancer Society, Florida Section

2003

Chair-Elect, American Chemical Society, Florida Section

2003

Program Chair, Florida Annual Meeting and Exposition of the American Chemical Society (FAME)

2002

Chair-Elect Designate, American Chemical Society, Florida Section

2001

Co-Chair, Protein Engineering Session, American Chemical Society, Southeast Region (SERMACS)

1997

Chair, Scientific Session, American Cancer Society, Florida Division

Community Outreach

2014

Raa Middle School Science Fair Judge

2010 - 2016

ChemWiki Consortium (http://chemwiki.ucdavis.edu)

2004, 2006, 2008, 2009

Godby High School Science Fair Judge

2002 - 2003

Chair, Alumni Newsletter Committee, FSU Department of Chemistry

2000, 2004

Chiles High School Science Fair Judge

1998, 1999, 2002, 2005, 2007, 2010, 2011

Capital Regional Science Fair Judge, Leon County

1997

Lincoln High School Science Fair Judge

Department/College/University Committees

2022 Sp

Chair, Promotion and Tenure Committee, Dept. Biomedical Sciences

2021 F - 2022 Sp

Faculty Senate Sexual Harassment Task Force, FSU

2021 F - 2023 F

Faculty Senate, FSU

2020 Su - 2023 Sp

Faculty Promotion Committee

2020 Su - 2023 Sp

Faculty Tenure Committee

2019 F -

Chair, Faculty Evaluation Committee

2019 F - 2021 F

Faculty Senate, FSU

2018 F -

Associate Chair for Research, Executive Committee, BMS

2018 Sp -

Foyer Design Committee, BMS

2017 Su - 2019 Su

Faculty Evaluation Committee, Biomedical Sciences

2017 Su -

Chair, Faculty Development and Mentoring Committee, BMS

2017 Su -

Faculty Space Committee, Biomedical Sciences

2017 Sp

University Research Misconduct Investigation Committee, FSU

2017 Sp - 2020 F

University Equipment and Infrastructure Enhancement Grant Program Subcommittee, FSU

2015 Su - 2017 Su

Faculty Evaluation Committee, Biomedical Sciences

2014 F - present

Medical Student Faculty Advisor, FSU College of Medicine

2014 F - 2016 F

Faculty Senate, FSU

2010 F

Program Publicity Committee, Program in Neuroscience

2010 Su

Mission Statement Committee, Biomedical Sciences

2010 Sp

Chair, Translational Science Laboratory Search Committee, FSU College of Medicine

2010 Sp

Faculty Evaluation Committee, BMS

2009 F - 2010 F

Web Site Development Committee, FSU College of Medicine

2009 F - 2019 Sp

Faculty Development Committee, BMS

2009 F - 2010 F

Neuroscience Graduate Program Committee

2009 F - 2010 F

Director, Invited Seminar Speaker Series, Biomedical Sciences

2007 F - 2008 Sp

Dean Search Committee, FSU College of Medicine

2006 F - 2012 F

Chair, Bylaws and Policy Committee, Biomedical Sciences

2006 F

Core Lab Faculty Users Committee, Biomedical Sciences

2006 F

Faculty Development Committee, Biomedical Sciences

2006 F

Chair, Graduate Recruiting and Admissions Committee, Biomedical Sciences

2006 F - present

Human Subjects Institutional Review Board, FSU

2005 F - 2007 F

Graduate Recruiting and Admissions Committee, Biomedical Sciences

2001 Su

Chemistry Screening Committee, CSIT Faculty Search, FSU

2000 Su - 2002 Su

Director, Graduate Recruiting and Admissions Committee, Department of Chemistry

2000 Sp

Computational Structural Biology 2001 Symposium Committee, FSU

2000 Sp - 2003 Su

Executive Committee, Department of Chemistry

2000 Sp - 2004 Sp

General Chemistry Committee, Department of Chemistry

2000 Sp

Molecular Recognition Initiative Building Committee, Department of Chemistry

1999 F

Merit Committee, Department of Chemistry

1999 Sp

Research Training Grant Computational Committee, FSU

1998 Sp - 2004 Sp

Structural Biology Scientific Advisory Committee, FSU

1998 Sp

Graduate Advising Policy Committee, Department of Chemistry

1997 F

Nominating Committee for Director, Institute of Molecular Biophysics

1997 F

Building Committee, Institute of Molecular Biophysics

1996 F, 2001 Sp - 2003 Su

Executive Committee, Institute of Molecular Biophysics

1996 F - 2004 Sp

Cell Culture Oversight Committee, Institute of Molecular Biophysics

1995 Sp - 1998 Sp, 2003 Sp - 2004 Sp

Graduate Student Selection Committee, Molecular Biophysics

1995 Sp

Michael Kasha Award Committee, Institute of Molecular Biophysics

1995 F - 2004 Sp

Graduate Recruiting and Advising Committee, Department of Chemistry

1995 F

Biochemistry Faculty Search Committee, Department of Chemistry

1995 F

Bylaws Committee, Department of Chemistry

1994 F

Biochemistry Faculty Search Committee, Department of Chemistry

1994 F

Organic Faculty Search Committee, Department of Chemistry

Research Funding

Date

Agency/PI

Project/Budget

12/18-1/19

FSU Council on Research and Creativity Planning Grant, Blaber, M. (PI)

Therapeutic Dose Response of FGF-1 in Pre-clinical Dermal Wound Healing, $13,000

5/17-5/18

FSU Institute for Successful Longevity Planning Grant, Blaber, M. (PI), Harper, K.M. (Co-PI)

Accelerating Healing of Ulcerative Dermal Wounds in the Aged, $15,000

5/16-4/17

FSU Research Foundation Equipment and Infrastructure Enhancement Grant, Blaber, M. (CoPI)

Acquisition of a Microscale Thermophoresis Instrument Useful for Sensitive Binding Affinity Measurements of Biomolecules, $60,000

3/15 - 3/21

Trefoil Therapeutics Inc.

Research Support Agreement, Blaber, M. (PI)

Biophysical Studies of FGF-1 Mutants, $300,000 ($197,368 direct)

12/12-1/13

FSU Council on Research and Creativity Planning Grant, Blaber, M. (PI)

Development of “Third-Generation” FGF-1 Mutants for Therapeutic Application, $26,000

1/12 -

12/12

Research Foundation, Application Proof of Concept (GAP) Grant, Blaber, M. (PI), Schlenoff, J. (Co-PI)

Novel Biocompatible Polymer Material Using Engineered Human Fibroblast Growth Factor-1 for Accelerated Wound healing. $50,000

2/11 - 1/12

Florida Department of Health Technology Transfer Feasibility Grant (1KF03), Blaber, M. (PI)

Development of "Second-Generation" Fibroblast Growth Factor-1 for Pro-Angiogenic Therapy, $99,350 ($86,391 direct)

12/10

FSU Research Foundation, Equipment and Infrastructure Enhancement Grant, Blaber, M. (Co-PI)

Acquisition of a Rigaku Automated Detector and X-Ray Generator System, $44,000

11/10

FSU College of Medicine Collaborative Project Exploration Grant, Blaber, M. (PI)

High Temperature “Crystals” of FGF-1 Mutants, $18,000

12/09

FSU College of Medicine Bridge Grant, Blaber, M. (PI)

Symmetric Deconstruction of Fibroblast Growth Factor-1, $40,000

6/09 - 8/10

NINDS Administrative Supplements for Summer Research Experiences, (1R15NS057771-01), Blaber, M. (PI)

$18,392

11/08

Enterprise Florida SBIR/STTR Phase 0 Pilot Program, Blaber, M. (PI)

Development of Second-generation Forms of Fibroblast Growth Factor-1 for Pro-angiogenic Therapy, $3,000

4/08 - 3/13

Dept. of Health and Human Services, Public Health Service (1R01NS052741-01A2) Scarisbrick, I.A. (PI), subcontract to Blaber, M.

Regulation and Function of Kallikreins in Spinal Cord Injury and Repair, $252,636 ($171,862 direct)

11/07

FSU Council on Research and Creativity Planning Grant, Blaber, M. (PI)

Combinatorial Protein Redesign for Enhanced Thermostability, $24,000

7/07

FSU Equipment and Infrastructure Enhancement Grant, Blaber, M. (Co-PI)

Critical Enhancements to Macromolecular X-ray Facility, $49,500

1/07-12/09

Dept. of Health and Human Services, Public Health Service (1R15NS057771-01), Blaber, M. (PI)

Interactions between CNS-specific Human Kallikreins and the PA System in Inflammation, $220,500 ($150,000 direct)

7/06 - 6/09

American Heart Association (0655133B), Blaber, M. (PI)

Characterization of Fibroblast Growth Factor-1 Mutants with Enhanced Properties for Angiogenic Therapy, $264,000 ($240,000 direct)

8/05

FSU Research Foundation  Application Proof of Concept (GAP) Grant, Blaber, M. (PI)

Heparin Binding Properties of Mutant FGF-1, $40,000

3/05 - 2/06

National Multiple Sclerosis Society - Pilot Award (PP1113), Blaber, M. (PI)

Identification of Activation Cascades Involving Human Kallikrein 6, $44,000 ($40,000 direct)

8/03 - 7/06

National Science Foundation (MCB 0314740), Blaber, M. (PI)

Probing the Role of Primary Sequence Asymmetry in a Symmetric Superfold, $391,660 ($280,357 direct)

4/03 - 7/03

Berlex Biosciences, Research Contract, Blaber, M. (PI)

Production of Recombinant Active Rat Kallikrein 6 Protein, $23,597 ($16,162 direct)

4/03 - 3/06

National Multiple Sclerosis Society (RG 3406-A-2), Blaber, M. (PI)

Regulation and Structural Study of a Novel Protease Implicated in Demyelination, $342,021 ($313,201 direct)

4/02

FSU Research Foundation, Cornerstone Program Enhancement Grant, Blaber, M. (PI)

The Role of a Newly-identified Enzyme in Multiple Sclerosis and Spinal Cord Damage, $99,652

11/01

FSU Council on Research and Creativity Planning Grant, Blaber, M. (PI)

Structure and Function Studies of Myelencephalon-specific Protease, an Enzyme Implicated in Nerve Damage and Multiple Sclerosis, $20,000

3/01

FSU Research Foundation Cornerstone Program Enhancement Grant, Blaber, M. (Co-PI)

Program in Real-Time Electron Paramagnetic Resonance for the Life and Chemical Sciences, $100,000

9/00 - 8/01

National Multiple Sclerosis Society - Pilot Award (PP0757), Blaber, M. (PI)

Enzymatic Characterization of a Novel CNS-specific Serine Protease, $27,500 ($25,000 direct)

12/00

FSU College of Arts and Sciences Graduate Recruiting Supplement, Blaber, M. (PI)

$7,000

1/00 - 12/03

American Heart Association, Established Investigator Grant (0040235N), Blaber, M. (PI)

Structure, Stability and Functional Studies of 2,5-Diketo-D-Gluconate Reductases, $299,453 ($272,230 direct)

12/99

Future Graph, Inc., Blaber, M. (PI)

Licensing of Web-based Undergraduate Chemistry Instructional Material, $3,000

5/99

FSU Distance Learning Course Development Grant, Blaber, M. (PI)

BCH5425 Molecular Biology and Biotechnology, $8,000

5/99

FSU Council on Research and Creativity Planning Grant, Blaber, M. (PI)

Protein Engineering of 2,5-diketo-D-Gluconate Reductase - An Enzyme for Vitamin C Biosynthesis, $12,000

3/99

FSU Research Foundation, Cornerstone Program Enhancement Grant, Blaber, M. (Co-PI)

Drug Development for Cystic Fibrosis, $100,000

11/98

FSU Distance Learning Course Development Grant, Blaber, M. (P.I.)

CHM1045 General Chemistry I, $8,000

5/98-4/99

Florida Space Grant Consortium, Blaber, M. (PI)

Deconvolution of Calorimetric Data for Protein Stability Studies, $14,000 (direct)

5/98

FSU Web Based Coursework Development Summer Grant, Blaber, M. (PI)

CHM1045 General Chemistry I, $5,200

11/96

FSU Council on Research and Creativity Planning Grant, Blaber, M. (PI)

Protease Structure and Specificity Relationships. $12,000

5/96-5/01

Dept. of Health and Human Services, Public Health Service (GM54429-01), Blaber, M. (PI)

Structure, Stability and Regulation of Human Acidic FGF, $500,000 ($350,000 direct)

4/96-5/99

American Heart Association, Blaber, M. (PI)

Design of a Thermostable Human Acidic Fibroblast Growth Factor, $270,000 ($255,000 direct) (Note: declined due to overlapping N.I.H. grant award)

6/96

MicroCal, Inc. Travel Award, Blaber, M.

1st International Conference on the Applications of Biocalorimetry, $500

4/96

Finn Wold Travel Award, Blaber, M.

1996 Protein Society Meeting, $400

6/95-5/96

American Cancer Society, Florida Division - Starter Grant (F95FU-1), Blaber, M. (PI)

The Role of Protein Stability in the Regulation of Human Acidic Fibroblast Growth Factor, $22,000 (direct)

5/95

FSU Council on Research and Creativity First Year Assistant Professor Award, Blaber, M. (PI)

A Study of Protein Structure and Stability Relationships. $8,900

Reviews/Journals Refereed/Professional Membership

Date

Invited Reviews/Editorials

2016

Myths and Verities in Protein Folding Theories, by Arieh Ben-Naim, Oxford University Press (2016) ISBN: 978-981-4725-98-9. Acta Cryst. D72, 1076-80, PMID: 27599740

2015

Production of Proteins from Cloned Genes, Ch. 9, Molecular Biotechnology, Garland Science Publishers

2010

The Essential Need for Protein Chemists, Blaber, M., Journal of Proteins and Proteomics, 1, 1-2

2005

Protein Structure and Function, prospectus review, Pearson Prentice Hall

2004

Nano-dynamics: Engineering Allostery via Tandem Duplication and Turn Energetics, Blaber, M. Trends Biotechnol. 22,1-2, PMID: 14690614

2004

Recombinant DNA - The Basics Series, Metzenberg, S., (review) Garland Science/BIOS Scientific Publishers

2003

Molecular Biology of the Gene (5th Edition) Watson (review, Chapter 8 - DNA Replication; Chapter 12 - Mechanisms of Transcription), Benjamin Cummings Publishers

2000

Biochemistry, The Chemical Reactions of Living Cells (2nd Edition) Metzler (review, Chapter 6 - Thermodynamics and Biochemical Equilibria), Harcourt Academic Press

2000

Cases in Industry Practice for Biotechnology (review), Pearson Publishing

1993

Alpha Helix Propensity of Amino Acids - Technical Note, Blaber, M., Zhang, X.-J. and Matthews, B.W., Science 262, 917-918

Journals Refereed

Protein Science

Proteins: Structure, Function and Genetics

Journal of Biological Chemistry

Biochemica et Biophysica Acta

Proceedings of the National Academy of Sciences

Journal of Molecular Biology

International Journal of Biological Macromolecules

Biochemistry

Journal of Physical Chemistry

Journal of Molecular Structure

Biochemical Journal

Crystal Growth & Design

International Journal of Biological Macromolecules

Cell Research

Acta Crystallographica Section F

European Biophysics Journal

Biological Chemistry

BioEssays

Cancer Biomarkers

PLoS ONE

Nature

EMBO J

Journal of Proteins and Proteomics

Archives of Biochemistry and Biophysics

Biomolecules

Journal of Pharmaceutical Sciences

Professional Memberships (past/present)

American Chemical Society

Biophysical Society

Protein Society

American Association for the Advancement of Science (AAAS)

Federation of American Societies for Experimental Biology (FASEB)

International Union of Crystallographers (IUCr)

American Society for Biochemistry & Molecular Biology (ASBMB)

Clinical Chemistry

Oral Research Presentations

Date

Title

Event

2020

Translational Research in Medicine: What, How, Who, Where and Why?

CELLS: Connecting Experiment, Lab & Life Sciences, FSU College of Medicine (Zoom)

2020

Dermal Wound Healing Intervention
with Wild-type FGF-1 in Aged BALB/cByJ Mice

Trefoil Therapeutics Research Symposium, San Diego (Zoom)

2019

Effective Recovery of Youthful Dermal Wound Healing in Aged Female BALB/cByJ Mice by Topical FGF-1

FSU Institute for Successful Longevity

2018

Fine-sampled Photographic Quantitation of Dermal Wound Healing Senescence in Aged BALB/cByJ Mice and Therapeutic Intervention with FGF-1

FSU Biomedical Sciences Seminar Series

2018

Structure and Stability of FGF-1 and the Design Strategy of Engineered FGFs

Trefoil Therapeutics Inc. Scientific Advisory Board Meeting, Ventura

2018

Sex and Age Effects on Excisional Dermal Wound Healing in BALB/cByJ Mice and Effects of Topical FGF-1/HS and TTHX1001 on Aged Mice

Trefoil Therapeutics Inc. Scientific Advisory Board Meeting, Ventura

2018

Medicine and Chemistry: Like Macaroni and Cheese

Department of Chemistry & Biochemistry Seminar Series, FSU

2016

The Ecstasy of Gold – Starting your Academic Research and Turning it into a Biotech Startup

Keynote Address, 4th Annual FSU Postdoctoral Symposium

2015

Protein Engineering: Three Tales

Department of Chemical and Biomedical Engineering, FSU

2014

Accelerated Dermal Healing by FGF-1 in the NONcNZO10/LtJ Diabetic Mouse

Fibroblast Growth Factors in Development & Disease Gordon Research Conference, Ventura

2014

Symmetry and simplicity in protein folding, evolution and design

FSU Bridge Program Seminar Series

2014

Symmetry and simplicity in protein folding, evolution and design

FSU Biomedical Sciences Seminar Series

2014

Symmetry and simplicity in protein folding, evolution and design

National Institute of General Medical Sciences (NIGMS)

2013

Development of second-generation forms of FGF-1 for therapeutic application

Shandong University of Medical Sciences, Jinan, China

2013

Development of Second-Generation Forms of FGF-1 for Therapeutic Application

Chinese Academy of Medical Sciences, Beijing, China

2013

Why is Symmetry so Fascinating (and Important) in Protein Structure, Folding, Evolution and Design?

Center for Scientific Review, National Institutes of Health

2013

Simplified Protein Design Biased for Pre-biotic Amino Acids Yields a Foldable Halophilic Protein

Halophiles 2013 International Meeting, U. Connecticut

2013

Prebiotic Protein Design: Effects of Aromatic Amino Acids

Florida A&M University NSF Research Experience for Undergraduates SEMINAR Series

2013

Prebiotic Protein Design and Proteogenesis

FSU Biomedical Sciences Seminar Series

2013

Prebiotic Protein Design and Proteogenesis

Japan Atomic Energy Agency, Tokai, Japan

2013

Animal models in the development of "2nd-Generation" fibroblast growth factor-1 mutants for accelerated healing

FSU Life Sciences Symposium

2012

Opportunities in Top-Down Symmetric Deconstruction

International Interdisciplinary Science Conference on Protein Folding and Disease, New Delhi, India

2012

Development of Second-Generation Forms of FGF-1 for Therapeutic Application

OMICS Group International Conference on Regenerative & Functional Medicine, San Antonio

2012

Animal Studies in the Development of "2nd-Generation" Fibroblast Growth Factor-1 Mutants for Accelerated Healing

Department of Physiological Sciences, College of Veterinary Sciences, University of Florida

2011

Functional Intersection of Matrix Metalloproteases with Kallikrein-Related Peptidases

4th International Symposium on Kallikreins, Rhodes Island, Greece

2011

Protein Engineering for Human Therapeutics

1st Annual FSU Life Sciences Symposium

2010

Experimental Support for the “Gene Duplication & Fusion” Hypothesis of Protein Evolution via a “Constant Architecture” Model

Department of Chemistry & Biochemistry, U. Arizona

2010

Deconstruction of a Symmetric Protein Superfold

Department of Pharmaceutical Chemistry, University of Kansas

2010

Human Kallikrein-related Peptidases (KLK’s): Activation Cascades and Inflammatory Demyelination

Neuroscience Symposium, Department of Psychology, FSU

2009

Structural Biology and Enzymology of the Human Kallikrein-related Peptidases, E.K. Frey-E. Werle Gold Medal Award acceptance speech

3rd International Symposium on Kallikreins and Kallikrein-related Peptidases, Munich, Germany

2009

Exploring Symmetric Protein Architecture by Structural Biology to Create an Artificial Protein

Japan Atomic Energy Agency, Tokai, Japan

2009

Symmetric Protein Architecture: Consequences for Protein Stability, Folding and Function

Advanced Technology Institute International Forum on Protein Structure Determination and Applications, Japan

2008

A Logical OR Redundancy within the Asx-Pro-Asx-Gly Type I beta-turn Motif

Northwest Crystallography Workshop (NWCW), Eugene

2008

Activation Profiles and Regulatory Cascades of the Human Kallikrein-related Peptidases

Department of Biophysics, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Brazil

2008

A Logical OR Redundancy within the Asx-Pro-Asx-Gly Type I beta-turn Motif

Japan Atomic Energy Research Institute, Tokai Japan

2008

Opportunities in the Design of Second-Generation Protein Therapeutics

5th Annual Conference on Regenerative Medicine, Las Vegas

2007

Activation Profiles and Regulatory Cascades of the Human Kallikrein-related Peptidases (KLKs)

2nd International Symposium on Kallikreins and Kallikrein-Related Peptidases, Santorini Island, Greece

2007

Solvent Structure in Protein Engineering of Human Fibroblast Growth Factor-1

Workshop on Neutron Protein Crystallography and its Perspective, Hitachi City, Japan

2007

The Latest in Molecular Architecture: Designing New Drugs

4th Annual Conference on Regenerative Medicine, Las Vegas

2006

Protein Engineering in the Development of a Novel Angiogenic Therapy for No-Option Coronary Heart Disease Patients

Grand Rounds, FSU College of Medicine

2006

Stability and Function in a Symmetric Protein Architecture

Department of Bioengineering, Kagoshima University, and Graduate School of Pharmaceutical Sciences, Kyushu University, Japan

2006

Confessions of a Molecular Architect

Ralph Alden Bradshaw 65th Birthday Symposium, Beckman Center of the National Academy of Arts and Sciences and Engineering, University of California, Irvine

2005

1.70Å X-Ray Structure of Human Apo Kallikrein 1: Structural Changes upon Peptide Inhibitor/Substrate Binding

1st International Conference on Kallikreins, Lausanne Switzerland

2005

Activation Cascades Involving the Human Kallikrein Family

Burnett College of Biomedical Sciences, University of Central Florida

2005

DSC: Data Analysis

Current Trends in Microcalorimetry Meeting, Boston

2005

Tertiary and Primary Structure Symmetry in Protein Evolution and Design

Department of Physiology and Biophysics, College of Medicine, UC Irvine

2005

The Role of Turn Regions in Protein Structure, Stability and Folding

Amgen Corp, Thousand Oaks

2005

Structure and Function Study of Human Kallikreins

FSU Biomedical Sciences Seminar Series

2005

Solvent Structure in the Active Site of Human Kallikrein 1: A Ghost in the Machine

International Workshop on Hydrogen and Hydration in Proteins and Nucleic Acids, University of Tokyo, Japan

2005

Kallikrein 6 and Inflammatory Demyelinating Disease

Dyax Corp., Boston

2004

Protein Symmetry, Stability and Function

CALCON 2004 - 59th Annual Calorimetry Conference, Santa Fe

2004

Structural Biology of Human Kallikreins 6 and 1

Department of Pathology, Mount Sinai Hospital, Toronto, Ontario Canada

2004

Structural Symmetry in Protein Evolution and Design

Department of Chemistry, Gettysburg College

2004

Structure and Function of Myelencephalon-specific Protease/Kallikrein 6: A Novel Serine Protease Expressed in the CNS and Implicated in Demyelinating Disease

The Blueprint of MS, MS Society, North Florida Chapter, Tallahassee Community College

2004

Structure and Function Studies of Myelencephalon-Specific Protease (MSP)/Kallikrein 6

Mayo Clinic, Jacksonville

2004

Structural Symmetry in a b-Trefoil - Implications for Protein Evolution and Design

Department of Chemistry & Biochemistry, FSU

2003

Structural Symmetry in a b-Trefoil - Implications for Protein Evolution and Design

School of Natural Sciences, U.C. Merced

2003

Structural Symmetry in a b-Trefoil - Implications for Protein Evolution and Design

Matthews Symposium, Eugene, OR

2002

Metabolic and Protein Engineering in the Development of a New Method for the Production of Vitamin C

Southeast Regional Meeting of the American Society for Microbiology, Gainesville

2002

DSC, Isothermal Equilibrium and Folding Kinetics of FGF - Getting it All to Agree

Trends in Biocalorimetry: Applications and Answers, Sealy Center for Structural Biology, UTMB Galveston

2002

DSC, Isothermal Equilibrium and Folding Kinetics of FGF - Getting it All to Agree

Current Trends in Biocalorimetry, North Carolina Biotechnology Center

2002

Structure and Function of Myelencephalon-specific Protease/Human Kallikrein 6: A Novel Serine Protease Expressed in the CNS and Implicated in Demyelinating Disease

Berlex Biosciences

2002

Crystal Packing Effects upon Protein Structures Determined by X-ray Crystallography

223rd American Chemical Society Meeting

2002

Structural Assembly of the Active Site in an Aldo-keto Reductase by NADPH Cofactor

Georgia State University Chemistry Seminar Series

2001

The Role of Symmetry in Protein Folding and Design

Florida Annual Meeting and Exposition of the American Chemical Society

2001

Stability and Dynamics Issues in Enzyme Engineering of an Aldo-keto Reductase

SERMACS 2001, Savannah GA

1999

The Role of Low Concentrations of Guanidine HCl in Reversible Denaturation of Human FGF-1

Sturtevant Biothermodynamics Symposium, Tallahassee

1999

The Role of Low Concentrations of Guanidine HCl in Reversible Denaturation of Human FGF-1

American Chemical Society Florida Annual Meeting and Exposition, Orlando

1999

Metabolic and Protein Engineering in the Development of a New Method for the Production of Vitamin C

Florida Institute of Technology

1998

Metabolic and Protein Engineering in the Development of a New Method for the Production of Vitamin C

Department of Chemistry Seminar Series, FSU

1998

Structure, Stability and Function of Human Acidic Fibroblast Growth Factor

Kirin Central Laboratory for Key Technology, Yokohama Japan

1998

Structure, Stability and Function of Human Acidic Fibroblast Growth Factor

Sagami Chemical Research Center, Sagamihara Japan

1998

Structure, Stability and Function of Human Acidic Fibroblast Growth Factor

International Institute for Advanced Research, Seika Japan

1997

Modulation of Protein Stability

Florida Annual Meeting and Exposition of the American Chemical Society

1997

Metabolic Engineering for the Production of Vitamin C: The Structure of 2,5-Diketo-D-Gluconate Reductase

Millsaps College

1997

Metabolic Engineering for the Production of Vitamin C: The Structure of 2,5-Diketo-D-Gluconate Reductase

University of South Florida

1997

Mechanisms of Regulation of Human Acidic Fibroblast Growth Factor

20th Annual Research Seminar American Cancer Society, Florida Division

1996

Denaturation Studies of Human Acidic Fibroblast Growth Factor

First International Conference on the Applications of Biocalorimetry

1996

Protein Structure, Stability and Function

Clarkson University

1995

Protein Stability as a Regulatory Mechanism

Florida Annual Meeting and Exposition of the American Chemical Society

Peer-Reviewed Publications

Date

Publication

PMID

2022

Creation of the intermolecular disulfide symmetry cross-linked crystal allowing observation of tertiary structures in different solvent conditions, Hiromoto, T., Ikura, T., Honjo, E., Blaber, M., Kuroki, R. and Tamada, T., Frontiers in Molecular Biosciences (in press)

 

2022

Variable and Conserved Regions of Secondary Structure in the β-trefoil Fold: Structure versus Function, Blaber, M., Frontiers in Molecular Biosciences (in press)

 

2022

Functionalization of a Symmetric Protein Scaffold: Redundant Folding Nuclei and Alternative Oligomeric Folding Pathways, Tenorio, C.A., Parker, J.B. and Blaber, M., Protein Science (in press)

35481645

2021

Regenerative Responses of Rabbit Corneal Endothelial Cells to Stimulation by Fibroblast Growth Factor 1 (FGF1) Derivatives, TTHX1001 and TTHX1114, Weant, J., Eveleth, D.D., Subramaniam, A., Jenkins-Eveleth, J., Blaber, M., Li, L., Ornitz, D.M., Alimardanov, A., Braodt, T., Dong, H., Vayas, V., Yang, X. and Bradshaw, R.A., Growth Factors (in press)

34879776

2021

The Ubiquitous Buried Water in the beta-Trefoil Architecture Contributes to the Folding Nucleus and ~20% of the Folding Enthalpy, Parker, J.B., Tenorio, C.A. and Blaber, M., Protein Science 30, 2287-2297

34562298

2021

Cooperative Hydrophobic Core Interactions in the β-trefoil Architecture, Blaber, M., Protein Science 30, 956-965

33686691

2020

Conserved Buried Water Molecules Enable the b-Trefoil Architecture, Blaber, M. Protein Science 29, 1794-1802

32542709

2020

A Bell-Shaped Dose Response of Topical FGF-1 in Dermal Wound Healing of Aged Female BALB/cByJ Mice, Hagerott, B.N., Blumstein, A.J., McGarry, L.E., Cohen, H.M., Tenorio, C.A., Powell, B.D., Nagy, T. and Blaber, M. Journal of Proteins and Proteomics 11, 183-191

 

2020

Oligomerization of a Symmetric β-trefoil Protein in Response to Folding Nucleus Perturbation Tenorio, C., Parker, J.B. and Blaber, M. Protein Science 29, 1629-1640

32362013

2020

Ab initio Folding of a Trefoil-fold Motif Reveals Structural similarity with a β-propeller Blade Motif, Tenorio, C., Longo, L.M., Parker, J.B., Lee, J. and Blaber, M. Protein Science 29, 1172-1185

32142181

2018

Fine-sampled Photographic Quantitation of Dermal Wound Healing Senescence in Aged BALB/cByJ Mice and Therapeutic Intervention with FGF-1, Mellers, A., Tenorio, C.A., Lacatusu, D., Powell, B., Patel, B., Harper, K.M. and Blaber, M. Advances in Wound Care 7, 409-418

31741752

2018

Crystal structure of glycosyltrehalose synthase from Sulfolobus shibatae DSM5389, Okazaki, N., Kato, M., Miura, Y., Kobayashi, K., Blaber, M., Kuroki, R. and Tamada, T. Acta Cryst. F74, 741-746

30387780

2018

A Mathematical Model for the Determination of Mouse Excisional Wound Healing Parameters from Photographic Data, Cogan, N.G., Mellers, A., Patel, B., Powell, B., Aggarwal, M., Harper, K.M. and Blaber, M., Wound Repair Regen. 26, 136-143

29663583

2018

Investigating Polyanion Binding Sites of Fibroblast Growth Factor-1 Using Hydrogen-Deuterium Exchange Mass Spectrometry, Angalakurthi, S.K., Tenorio, C.A., Blaber, M. and Middaugh, C.R., Protein Science 27, 1068-1082

29645318

2017

Folding Nucleus Structure Persists in Thermally-aggregated FGF-1, Longo, L.M., Gao, Y., Tenorio, C.A., Wang, G., Paravastu, A.K. and Blaber, M., Protein Science 2017 Oct 27. doi: 10.1002/pro.3332. [Epub ahead of print]. 2018 27,431-440

29076579

2016

An S116R Phosphorylation Site Mutation in Human FGF-1 Differentially Affects Mitogenic and Glucose Lowering Activities, Xia, X., Kumru, O.S., Blaber, S.I., Middaugh, C.R., Li, L., Ornitz, D.M., Suh, J.M., Atkins, A.R., Downes, M., Evans, R.M., Tenorio, C.A., Bienkiewicz, E. and Blaber, M., J. Pharm. Sci. 105, 3507-19

27773526

2016

An Insight into the Thermodynamic Characteristics of Human Thrombopoietin Complexation with TN1 Antibody, Arai, S., Shibazaki, C., Adachi, M., Honjo, E., Tamada, T., Maeda, Y., Tahara, T., Kato, T., Miyazaki, H., Blaber, M. and Kuroki, R., Protein Sci. 25, 1786-96

27419667

2016

Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "2nd Generation" Therapeutic Application, Xia, X., Kumru, O.S., Blaber, S.I., Middaugh, C.R., Li, L., Ornitz, D.M., Sutherland, M.A., Tenorio, C. and Blaber, M., J. Pharm. Sci. 105, 1444-53

27019961

2016

Evolution of a Protein Folding Nucleus, Xia, X., Longo, L.M., Sutherland, M.A. and Blaber, M., Protein Science 25, 1227-40, Protein Evolution and Design” special issue

26610273

2015

Pharmacological Activities and Hydrolysis by Peptidases of [Phospho-Ser6]-Bradykinin (pS6-BK), Assis, D.M., Juliano, L., Paschoalin, T., Kouyoumdjian, M., Calixto, J.B., Santos, R.A.R., Perinhez, T.A., Gauthier, F., Moureau, T., Blaber, M. and Juliano, M.A., Biochemical Pharmacology 97, 203-14

26235942

2015

Accelerated Healing in NONcNZO10/LtJ Type 2 Diabetic Mice by FGF 1, Blaber, S.I., Diaz, J. and Blaber, M., Wound Repair Regen. 23, 538-49

25891187

2015

Structure of a Highly Acidic β-lactamase from the Moderate Halophile Chromohalobacter sp. 560 and the Discovery of a Cs+ Selective Binding Site, Arai, S., Yonezawa, Y., Okazaki, N., Matsumoto, F., Shibazaki, C., Shimizu, R., Yamada, M., Adachi, M., Tamada, T., Kawamoto, M., Tokunaga, H., Ishibashi, M., Blaber, M., Tokunaga, M. and Kuroki, R., Acta Crystallogr D Biol Crystallogr. 71, 541-54

25760604

2015

Structural Basis for Acceptor-substrate Recognition of UDP-glucose: Anthocyanidin 3-O-glucosyltransferase from Clitoria ternatea, Hiromoto, T., Honjo, E., Tamada, T., Noda, N., Kazuma, K., Suzuki, M., Blaber, M. and Kuroki, R., Protein Science 24, 395-407, Cover article

25556637

2015

Specificity Studies on Kallikrein-related Peptidase 7 (KLK7) and Effects of Osmolytes and Glycosaminoglycans on its Peptidase Activity, Oliveira, J.R., Bertolin, T.C., Andrade, D., Oliveira, L.C., Kondo, M.Y., Santos, J.A., Blaber, M., Juliano, L., Severino, B., Caliendo, G., Santagada, V. and Juliano, M.A., Biochimica et Biophysica Acta – Proteins and Proteomics 1854, 73-83

25448018

2015

Mutation Choice to Eliminate Buried Free Cysteines in Protein Therapeutics, Xia, X., Longo, L.M. and Blaber, M., J. Pharm. Sci. 104, 566–76 Two Decades of Publishing Excellence in Biotechnology” special issue

25312595

2015

A Single Aromatic Core Mutation Converts a Designed "Primitive" Protein from Halophile to Mesophile Folding, Longo, L.M., Tenorio, C.A., Kumru, O.S., Middaugh, C.R. and Blaber, M., Protein Science 24, 27–37

25297559

2014

Evolution and Design of Protein Structure by Folding Nucleus Symmetric Expansion, Longo, L.M., Kumru, O.S., Middaugh, C.R. and Blaber, M., Cell: Structure 22, 1377-84

25242458

2014

Symmetric Protein Architecture in Protein Design: Top-Down Symmetric Deconstruction, Longo, L. and Blaber, M., in Protein Design, Meth. Molec. Biol. 1216:161-82, Cover article

25213415

2014

Isomannide-Based Peptidomimetics as Inhibitors for Human Kallikreins 5 and 7, Oliveira, J.P.C., Freitas, R.F., Freire, E., Barros, T.G., Santos, J.A.N., Juliano. M..A., Pinheiro, S., Blaber, M., Muri, E.M.F. and Puzer, L., Medicinal Chem. Lett. 5, 128–32

24900785

2014

Structural Characteristics of Alkaline Phosphatase from the Moderately Halophilic Bacteria Halomonas sp.593, Araia,S., Yonezawa,Y., Ishibashi, M., Matsumoto,  F., Adachi, M., Tamada, T., Tokunaga, H., Blaber, M., Tokunaga, M. and Kuroki, R., Acta Crystallogr. D Biol. Crystallogr. 70,811-20

24598750

2014

Prebiotic Protein Design Supports a Halophile Origin of Foldable Proteins, Longo, L.M. and Blaber, M., Frontiers in Extreme Microbiology 4, 1-3

24432016

2013

Biophysical Characterization of a Thermoalkalophilic Esterase from Geobacillus sp., Longo, L.M., Şanlı-Mohamed, G. and Blaber, M., J. Proteins Proteomics 4, 123-8

 

2013

Kallikrein-related Peptidase 6: A Biomarker for Traumatic Brain Injury in Rat, Phipps, H., Longo, L., Blaber, S.I., Blaber, M. and VanLandingham,J., Brain Injury 27, 1698-1706

24266798

2013

Alternative Folding Nuclei Definitions Facilitate the Evolution of a Symmetric Protein Fold from a Smaller Peptide Motif, Longo, L.M., Lee, J., Tenorio, C.A. and Blaber, M., Cell: Structure 21, 1-9

24139990

2013

Kallikrein Cascades in Traumatic Spinal Cord Injury: Differential Roles in Axonopathy and Neurodegeneration, Radulovic, M., Yoon, H., Wu, J., Larson, N., Linbo, R., Burda, J.E., Diamandis, E.P., Blaber, S.I., Blaber, M., Fehlings, M.G. and Scarisbrick, I.A., Journal of Neuropathology & Experimental Neurology 72, 1072-89

24128681

2013

Creation and Structure Determination of an Artificial Protein with Three Complete Sequence Repeats, Adachi, M., Shimizua, R., Kuroki, R. and Blaber, M., Journal of Synchrotron Radiation 20, 953-7

24121347

2013

Kallikrein 6 Signals through PAR1 and PAR2 to Promote Neuron Injury and Exacerbate Glutamate Neurotoxicity, Yoon, H., Radulovic, M., Wu, J., Blaber, S.I., Blaber, M., Fehlings, M.G. and Scarisbrick, I.A., J. Neurochem. 127, 283-98

23647384

2013

Human Tissue Kallikreins 3 and 5 can Act as Plasminogen Activator Releasing Active Plasmin, de Souza, L.R., Saud, P., Paschoalin, T., Carmona, A.K., Kondo, M., Hirata, I.Y., Blaber, M., Tersariol, I., Takatsuka, J., Juliano, M.A., Juliano, L., Gomes, R.A. and Puzer, L., Biochem. Biophys. Res. Comm. 433, 333-7

23500465

2013

Simplified Protein Design Biased for Pre-Biotic Amino Acids Yields a Foldable, Halophilic Protein, Longo, L., Lee, J. and Blaber, M., Proc. Natl. Acad. Sci. U S A.  110, 2135-9, Kasha Award for best paper in molecular biophysics; Faculty of 1000 citation

23341608

2013

Clinical Significance and Novel Mechanism of Action of Kallikrein 6 in Glioblastoma, Drucker, K.L., Paulsen, A.R., Giannini, C., Decker, P.A., Blaber, S.I., Blaber, M., Uhm, J.H., O'Neill, B.P., Jenkins, R.B. and Scarisbrick, I.A., Neuro-Oncology 15, 305-18

23307575

2013

Activation Profiles of Human Kallikrein-related Peptidases by Matrix Metalloproteinases, Yoon, H., Blaber, S.I., Li, W., Scarisbrick, I.A. and Blaber, M., Biological Chemistry 394, 137-47

23241590

2012

Protein Design -- A Vast Unexploited Resource, Longo, L.M. and Blaber, M., Journal of Proteins and Proteomics, 3, 77-81

 

2012

Pharmacokinetic Properties of 2nd-Generation Fibroblast Growth Factor-1 Mutants for Therapeutic Application, Xia, X., Babcock, J.P., Blaber, S.I., Harper, K.M. and Blaber, M., PLoS ONE 7(11): e48210

23133616

2012

Experimental Support for the Foldability-Function Tradeoff Hypothesis:  Segregation of the Folding Nucleus and Functional Regions in FGF-1, Longo, L., Lee, J. and Blaber, M., Protein Science 21, 1911-20, Protein Science Best Paper Award

23047594

2012

Isomannide Derivatives as New Class of Inhibitors for Human Kallikrein 7, Freitas, R.F., Teixeira, T.S., Abrahao, O.Jr., Barros, T.G., Santos, J.A., Kondo, M.Y., Juliano, M.A., Blaber, s.I., Blaber, M., Juliano, L., Antunes, O.A., Muri, E.M., and Puzer, L., Bioorg. Med. Chem. Lett. 22, 6072-5

22959247

2012

Emergence of Symmetric Protein Architecture from a Simple Peptide Motif: Evolutionary Models, Blaber, M., Lee, J. and Longo, L., Cellular and Molecular Life Sciences 69, 3999-4006

22790181

2012

Protein Design at the Interface of the Pre-Biotic and Biotic Worlds, Longo, L.M. and Blaber, M., Archives of Biochemistry & Biophysics 526, 16-21

22772066

2012

Structure and Function of d1-Tetrahydrocannabinolic Acid (THCA) Synthase, the Enzyme Controlling the Psychoactivity of Cannabis sativa, Shoyama, Y., Tamada, T., Kurihara, K., Takeuchi, A., Taura, F., Arai, S., Blaber, M., Shoyama, Y., Morimoto, S. and Kuroki, R., J. Mol. Biol. 423, 96-105, Cover article

22766313

2012

Designing Proteins from Simple Motifs: Opportunities in Top-Down Symmetric Deconstruction, Blaber, M. and Lee, J., Current Opinion in Structural Biology 22, 442-50

22726756

2012

Kallikrein 6 is a Novel Molecular Trigger of Reactive Astrogliosis, Scarisbrick, I., Radulovic, M., Burda, J., Larson, N., Blaber, S., Gianinni, C., Blaber, M. and Vandell, A., Biol. Chem. 393, 355-67

22505518

2012

Kallikrein 6 Regulates Early CNS Demyelination in a Viral Model of Multiple Sclerosis, Scarisbrick, I.A., Yoon, H., Panos, M., Larson, N., Blaber, S.I., Blaber, M. and Rodriguez, M., Brain Pathol. 22, 709-22

22335454

2012

Substrate Recognition Mechanism of a Glycosyltrehalose Trehalohydrolase (Gthase) from Sulfolobus Solfataricus KM1, Okazaki, N., Tamada, T., Feese, M.D., Kato, M., Miura, Y., Komeda, T., Kobayashi, K., Kondo, K., Blaber, M. and Kuroki, R., Protein Science 21, 539-52

22334583

2012

A Structural Mechanism for Dimeric to Tetrameric Oligomer Conversion in Halomonas sp. Nucleoside Diphosphate Kinase, Arai S, Yonezawa Y, Okazaki N, Matsumoto F, Tamada T, Tokunaga H, Ishibashi M, Blaber M, Tokunaga M, and Kuroki R., Protein Science 21, 498-510

22275000

2012

An Empirical Phase Diagram Approach to Investigate Conformational Stability of "Second-Generation" Functional Mutants of Acidic Fibroblast Growth Factor (FGF-1), Alsenaidy, M.A., Wang, T., Kim, J.H., Joshi, S.B., Lee, J., Blaber, M., Volkin, D.B., and Middaugh, C.R., Protein Science 21, 418-32

22113934

2011

Biological Evaluation and Docking Studies of Natural Isocoumarins as Inhibitors for Human Kallikrein 5 and 7, Teixeira, T.S., Freitas, R,F., Abrahão, O. Jr, Devienne, K.F., de Souza, L.R.,Blaber, S.I., Blaber, M., Kondo, M.Y., Juliano, M.A., Juliano, L. and Puzer, L., Bioorg. Med. Chem. Lett. 21, 6112-5

21903387

2011

Expression and Function of the Kallikrein-Related Peptidase 6 in the Human Melanoma Microenvironment, Krenzer, S., Peterziel, H., Mauch, C., Blaber, S.I., Blaber, M., Angel, P. and Hess, J., J. Invest. Dermatol.131, 2281-8

21753781

2011

Substrate Specificity of Kallikrein-Related Peptidase 13 Activated by Salts or Glycosaminoglycans and a Search for Natural Substrate Candidates, Andrade, D., Assis, D.M., Santos, J.A.N., Alves, F.M., Hirata, I.Y., Araujo, M.S., Blaber, S.I., Blaber, M., Juliano, M.A. and Juliano, L., Biochimie 93, 1701-9

21689719

2011

Functional Role of Kallikrein 6 in Regulating Immune Cell Survival, Scarisbrick, I.A., Epstein, B., Cloud, B., Yoon, H., Wu, J., Blaber, S.I., Blaber, M., Vandell, A.G. and Bryson, A. PLoS ONE 6(3): e18376

21464892

2011

A Polypeptide "Building Block" for the ß-Trefoil Fold Identified By "Top-Down Symmetric Deconstruction", Lee, J., Blaber, S., Dubey, V. and Blaber, M., J. Mol. Biol. 407, 744–63 Cover article, Faculty of 1000 citation

21315087

2011

Experimental Support for the Evolution of Symmetric Protein Architecture from a Simple Peptide Motif, Lee, J. and Blaber, M., Proc. Natl. Acad. Sci. 108, 126-30 Faculty of 1000 citation

21173271 

2010

Increased Functional Half-life of Fibroblast Growth Factor-1 by Recovering a Vestigial Disulfide Bond, Lee, J. and Blaber, M., J. Proteins Proteomics, 1, 37-42

 

2010

Substrate Specificity and Inhibition of Human Kallikrein-Related Peptidase 3 (KLK3 Or PSA) Activated with Sodium Citrate and Glycosaminoglycans., Andrade, D., Assis, D.M., Lima, A.R., Oliveira, J.R., Araujo, M.S., Blaber, S.I., Blaber, M., Juliano, M.A. and Juliano, L., Arch. Biochem. Biophys. 498, 74-82

20371359

2010

Functional Intersection of the Kallikrein-Related Peptidases (Klks) and Thrombostasis Axis, Blaber, M., Yoon, H., Juliano, M.A., Scarisbrick, I.A., and Blaber, S.I., Biological Chemistry 391, 311-20

20128685

2009

Engineering an Improved Crystal Contact Across a Solvent-Mediated Interface of Human Fibroblast Growth Factor-1, Meher, A.K., Blaber, S.I., Lee, J., Honjo, E., Kuroki, R. and Blaber, M., Acta Cryst. F. 65, 1136-40

19923735

2009

X-ray Structure and Biophysical Properties of Rabbit Fibroblast Growth Factor-1, Lee, J., Blaber, S.I., Irsigler, A., Aspinwall, E. and Blaber, M., Acta Cryst. F. 65, 1097-104

19923726

2009

Analysis of the Dynamics of Assembly and Structural Impact for a Histidine Tagged FGF-1 – 1.5 nm Au Nanoparticle Bioconjugate, Kogot, J.M., Parker, A.M., Lee, J., Blaber, M., Strouse, G.F. and Logan, T.M., Bioconjugate Chemistry 20, 2106-13

19810698

2009

The Interaction between Thermodynamic Stability and Buried Free Cysteines in Regulating the Functional Half-life of Fibroblast Growth Factor-1, Lee, J. and Blaber, M., J. Mol. Biol. 393, 113-27

19695265

2009

Structural Basis of Conserved Cysteine in the Fibroblast Growth Factor Family: Evidence for a Vestigial Half-cystine, Lee, J. and Blaber, M., J. Mol. Biol. 393, 128-39

19683004

2009

A Completed KLK Activome Profile: Investigation of Activation Profiles of KLK9, 10 and 15, Yoon, H., Blaber, S.I., Debela, M., Goettig, P., Scarisbrick, I.A. and Blaber, M., Biological Chemistry 390, 373-7

19090718

2008

S(1)’ and S(2)’ Subsite Specificities of Human Plasma Kalikrein and Tissue Kallikrein 1 on the Hydrolysis of Peptides Derived from Bradykinin Domain of Human Kininogen., Lima, A.R., Alves, F.M., Angelo, P.F., Andrade, D., Blaber, S.I., Blaber, M., Juliano.L. and Juliano, M.A., Biological Chemistry 389, 1487-94

18844446

2008

Protease Activated Receptor Dependent and Independent Signaling by Kallikreins 1 and 6 in CNS Neuron and Astroglial Cell Lines, Vandell, A.G., Larson, N., Laxmikanthan, G., Panos, M., Blaber, S.I., Blaber, M. and Scarisbrick, I.A., J. Neurochem. 107, 855-70

18778305

2008

Activation Profiles of Human Kallikrein-related Peptidases by Proteases of the Thrombostasis Axis, Yoon, H., Blaber, S.I., Evans, D.M., Trim, J., Juliano, M.A., Scarisbrick, I.A. and Blaber, M., Prot. Sci. 17, 1998-2007

18697857

2008

Kallikreins are Associated with Secondary Progressive Multiple Sclerosis and Promote Neurodegeneration, Scarisbrick, I.A., Linbo, R., Vandell, A.G., Keegan, M., Blaber, S.I., Blaber, M., Sneve, D., Lucchinetti, C.F., Rodriguez, M. and Diamandis, E.P., Biol. Chem. 389, 739-45

18627300

2008

Mutagenesis of the Crystal Contact of Acidic Fibroblast Growth Factor, Honjo, E., Tamada, T., Adachi, M., Kuroki, R., Meher, A. and Blaber, M., J. Synchrotron Radiation 15, 285-7

18421160

2008

Substrate Specificity of Human Kallikreins 1 and 6 Determined by Phage Display, Li, H.-X., Hwang, B.-Y., Laxmikanthan, G., Blaber, S.I., Blaber, M., Golubkov, P.A., Ren, P., Iverson, B.L. and Georgiou, G., Protein Science 17, 664-72

18359858

2008

A Logical OR Redundancy within the Asx-Pro-Asx-Gly Type I b-turn Motif, Lee, J., Dubey, V.K., Longo, L.M. and Blaber, M., J. Mol. Biol. 377, 1251-64

18308335

2007

Activation Profiles and Regulatory Cascades of the Human Kallikrein-related Peptidases, Yoon, H., Laxmikanthan, G., Lee, J., Blaber, S.I., Rodriguez, A., Kogot, J.M., Scarisbrick. I.A. and Blaber, M., J. Biol. Chem. 282, 31852-64

17823117

2007

Spackling the Crack: Stabilizing Human Fibroblast Growth Factor-1 by Targeting the N- and C-terminus b-strand Interactions, Dubey, V.K., Lee, J., Somasundaram, T., Blaber, S. and Blaber, M., J. Mol. Biol. 371, 256-68

17570396

2007

The Autolytic Regulation of Human Kallikrein-Related Peptidase 6, Blaber, S., Yoon, H., Scarisbrick, I.A., Juliano, M.A., and Blaber, M., Biochemistry 46, 5209-17

17417874

2006

Dynamic Role of Kallikrein 6 in Traumatic Spinal Cord Injury, Scarisbrick, I.A., Sabharwal, P., Blaber, S.I., Cruz, H., Ameednuddin, S., Papke, L.M., Larsen, N., Fehlings, M.G., Reeves, R.K., Blaber, M., Windebank, A.J. and Rodriguez, M., Eur. J. Neurosci. 24, 1457-69

16987227

2006

Proteinase-activated Receptors, Targets for Kallikrein Signalling, Oikonomopoulou, K., Hansen, K.K., Saifeddine, M., Tea, I., Blaber, M., Blaber, S.I., Scarisbrick, I.A., Andrade-Gordon, P., Cottrell, G.S., Bunnett, N.W., Diamandis, E.P. and Hollenberg, M.D., J. Biol. Chem. 281, 32095-112

16885167

2006

Potential Scope of Action of Tissue Kallikreins in CNS Immune-Mediated Disease, Scarisbrick, I.A., Blaber, S.I., Tingling, J.T., Rodriguez, M., Blaber, M, and Christophi, G.P., J. Neuroimmunol. 178, 167-76

16824622

2006

Kallikrein-Mediated Cell Signaling: Targeting Proteinase-Activated Receptors (PARs)1, Oikonomopoulou, K., Hansen, K.K., Saifeddine, M., Vergnolle, N., Tea, I., Blaber, M., Blaber, S.I., Scarisbrick, I., Diamandis, E.P. and Hollenberg, M.D., Biological Chemistry 387, 817-24

16800746

2006

A Comprehensive Nomenclature for Serine Proteases with Homology to the Tissue Kallikrein, Lundwall, A Band, V., Blaber, M., Clements, J., Courty, Y., Diamandis, E., Lilja, H., Maltais, L.J., Olsson, Y., Petraki, C., Sotiropoulou, G., Stenman, U.-H., Stephan, C., Talieri, M. and Yousef, G., Biological Chemistry 387, 637-41

16800724

2006

Conversion of Type I 4:6 to 3:5 b-turn Types in Human Acidic Fibroblast Growth Factor: Effects upon Structure, Stability, Folding and Mitogenic Function, Lee, J., Dubey, V.K., Somasundaram, T. and Blaber, M., Proteins 62, 686-97

16355415

2006

Substrate Specificity of Human Kallikrein 6: Salt and Glycosaminoglycan Activation Effects, Angelo, P.F., Lima, A.R., Alves, F.M., Juliano, L., Blaber, S.I., Scarisbrick, I.A., Blaber, M. and Juliano, M.A., J. Biol. Chem. 281, 3116-26

16321973

2005

Redesigning Symmetry-Related “Mini-Core” Regions of FGF-1 to Increase Primary Structure Symmetry: Thermodynamic and Functional Consequences of Structural Symmetry, Dubey, V.K., Lee, J. and Blaber, M., Protein Science 14:2315-23

16081654

2005

Structural and Energetic Consequences of Mutations in a Solvated Hydrophobic Cavity, Adamek, D.H., Guerrero, L., Blaber, M. and Caspar, D.L.D., J. Mol. Biol. 346, 307-18

15663946

2005

1.70Å X-ray Structure of Human Apo Kallikrein 1: Structural Changes upon Peptide Inhibitor/substrate Binding, Laxmikanthan, G., Blaber, S.I., Bernett, M.J., Scarisbrick, I.A., Juliano, M.A. and Blaber, M., Proteins 58, 802-14

15651049

2005

Sequence-Swapping does not Result in Conformation-Swapping for the b4/b5 and b8/b9 b-Hairpin Turns in Human Acidic Fibroblast Growth Factor, Kim, J., Lee, J., Brych, S.R., Logan, T.M. and Blaber, M., Protein Science 14, 351-359, Faculty of 1000 citation

15632285 

2004

Distinct Promoters Regulate Tissue-specific and Differential Expression of Kallikrein 6 in CNS Demyelinating Disease, Christophi, G.P., Isackson, P.J., Blaber, S., Blaber, M., Rodriguez, M. and Scarisbrick, I.A., Journal of Neurochemistry 91, 1439-49

15584920

2004

Symmetric Primary And Tertiary Structure Mutations Within A Symmetric Superfold: A Solution, Not A Constraint, To Achieve A Foldable Polypeptide, Brych, S.R., Dubey, V.K., Bienkiewicz, E., Lee, J., Logan, T.M. and Blaber, M., J. Mol. Biol. 344, 769-80

15533444

2004

An Atomic Resolution Structure for Human Fibroblast Growth Factor-1, Bernett, M.J., Somasundaram, T. and Blaber, M., Proteins: Structure, Function and Bioinformatics 57, 626-34, Cover article

15382229  

2004

Targeting Kallikrein 6 Proteolysis Attenuates CNS Inflammatory Demyelinating Disease, Blaber, S., Ciric, B., Bernett, M., Blaber, M., Rodriguez, M. and Scarisbrick, I.A., FASEB J. 18, 920-2

15033932

2004

Structural Alteration of Cofactor Specificity in Corynebacterium 2,5-diketo-D-Gluconic Acid Reductase, Sanli, G., Banta, S., Anderson, S. and Blaber, M., Protein Science 13, 504-12

14718658

2003

Accommodation of a Highly Symmetric Core within a Symmetric Protein Superfold, Brych, S.R., Kim, J., Logan, T.M. and Blaber, M., Protein Science 12, 2704-18, Cover article

14627732

2003

Identification of a Key Structural Element for Protein Folding within b-Hairpin Turns, Kim, J., Brych, S.R., Lee, J., Logan, T.M. and Blaber, M., J. Mol. Biol. 328, 951-61

12729767

2003

Structural Biology of the Aldo-keto Reductase Family of Enzymes: Catalysis and Cofactor Binding, Sanli, G., Dudley, J.I. and Blaber, M., Cell Biochem. Biophys. 38, 79-101

12663943

2002

Activity of a Newly Identified Serine Protease in Oligodendrocyte Biology and Demyelination, Scarisbrick, I.A., Blaber, S.I., Lucchinetti, C.F., Genain, C.P., Blaber, M. and Rodriguez, M., Brain 125, 1-14

12023317

2002

Crystal Structure and Biochemical Characterization of Human Kallikrein 6 Reveals a Trypsin-like Kallikrein is Expressed in the Central Nervous System, Bernett, M.J., Blaber, S.I., Scarisbrick, I.A., Dhanarajan, P., Thompson, S.M., and Blaber, M., J. Biol. Chem 277, 24562-70

11983703

2002

Alternative Type I and I' Turn Conformations in the b8/b9 b-hairpin of Human Acidic Fibroblast Growth Factor, Kim, J., Blaber, S.I., and Blaber, M., Protein Science 11, 459-66

11847269

2002

Enzymatic Properties of Rat Myelencephalon Specific Protease, Blaber, S.I., Scarisbrick, I.A., Bernett, M.J., Dhanarajan, P., Seavy, M.A., Jin, Y., Schwartz, M.A., Rodriguez, M. and Blaber, M., Biochemistry 41, 1165-73

11802715

2001

Structure and Stability Effects of Mutations Designed to Increase the Primary Sequence Symmetry within the Core Region of a b-Trefoil , Brych, S.R., Blaber, S.I., Logan, T.M. and Blaber, M., Protein Science 10, 2587-99

11714927

2001

An Efficient, Flexible-Model Program for the Analysis of Differential Scanning Calorimetry Data , Grek, S., Davis, J. and Blaber, M., Protein and Peptide Letters 6, 429-36

 

2001

Structural Assembly of the Active Site in an Aldo-keto Reductase by NADPH Cofactor, Sanli, G. and Blaber, M., Journal of Molecular Biology 309, 1209-18

11399090

2001

 Reduction of Wobble-position GC Bases in Corynebacteria Genes and Enhancement of PCR and Heterologous Expression, Sanli, G., Blaber, S.I. and Blaber, M., Journal of Molecular Microbiology and Biotechnology 3, 123-6

11200224

2000

Thermodynamic Characterization of Mutants of Human FGF-1 with an Increased Physiological Half-life, Culajay, J.F., Blaber, S.I., Khurana, A. and Blaber, M., Biochemistry 39, 7153-8

10852713

2000

Preferential Expression of Myelencephalon Specific Protease by Oligodendrocytes of the Adult Rat Spinal Cord White Matter, Scarisbrick, I.A., Asakura, K., Blaber, S., Blaber, M., Isackson, P.J., Bieto, T., Rodriguez, M. and Windebank, A.J., Glia 30, 219-30

10756072

2000

Molecular Modeling of Substrate Binding in Wild Type and Mutant Corynebacteria 2,5-Diketo-D-Gluconate Reductase, Khurana, S., Sanli, G., Powers, D.B., Anderson, S.A. and Blaber, M., Proteins: Structure, Function and Genetics 39, 68-75

10737928

1999

Reversible Thermal Denaturation of Human FGF-1 Induced by Low Concentrations of Guanidine Hydrochloride, Blaber, S.I., Culajay, J.F., Khurana, A. and Blaber, M., Biophysical Journal 77, 470-7

10388772

1999

Disordered Water within a Hydrophobic Protein Cavity Visualized by X-Ray Crystallography, Yu, B., Blaber, M., Gronenborn, A.M., Clore, G.M. and Caspar, D.L.D., Proceedings of the National Academy of Sciences 96, 103-8

9874779

1998

Crystal Structure of 2,5-diketo-D-gluconate Reductase A Complexed with NADPH at 2.1Resolution, Khurana, S., Powers, D.B., Anderson, S.A. and Blaber, M., Proceedings of the National Academy of Sciences 95, 6768-73

9618487

1997

Preliminary X-Ray Crystallographic Analysis and Molecular Replacement Studies with 2,5-Diketo-Gluconate Reductase, Khurana, S., Powers, D.B., Anderson, S. and Blaber, M., Protein and Peptide Letters 4, 287-90

 

1997

Crystallization and Preliminary X-ray Analysis of Mouse Pro-Renin Converting Enzyme, Blaber, M., Protein and Peptide Letters 4, 207-10

 

1996

X-ray Crystal Structure of Human Acidic Fibroblast Growth Factor, Blaber, M., DiSalvo, J. and Thomas, K.A., Biochemistry 35, 2086-94

8652550

1995

Alanine Scanning Mutagenesis in the Helix 115-123 of Phage T4 Lysozyme: Effects upon Structure, Stability and Solvent Accessibility, Blaber, M., Baase, W.A., Gassner, N. and Matthews, B.W., J. Mol. Biol. 246, 317-30

7869383

1994

Accomodation of Amino Acid Insertions in an α-Helix of T4 Lysozyme: Structural and Thermodynamic Analysis, Heinz, D.W., Baase, W.A., Zhang, X.-J., Blaber, M., Dahlquist, F.W. and Matthews, B.W., J. Mol. Biol. 236, 869-86

8114100

1994

Determination of α-helix Propensity within the Context of a Folded Protein: Sites 44 and 131 in Bacteriophage T4 Lysozyme, Blaber, M., Zhang, X.-J., Lindstrom, J.D., Pepiot, S.D., Baase, W.A. and Matthews, B.W., J. Mol. Biol. 235, 600-24

8289284

1993

Energetic Cost and Structural Consequences of Burying a Hydroxyl Group within the Core of a Protein Determined from AlaSer and ValThr Substitutions in T4 Lysozyme, Blaber, M., Lindstrom, J.D., Gassner, N., Xu, J., Heinz, D.W. and Matthews, B.W., Biochemistry 32, 11363-73

8218201

1993

Prediction of the Three-dimensional Structures of the Nerve Growth Factor and Epidermal Growth Factor Binding Proteins (Kallikreins) and an Hypothetical Structure of the High Molecular Weight Complex of Epidermal Growth Factor with its Binding Protein, Bax, B., Blaber, M., Ferguson, G., Sternberg, M.J.E. and Walls, P.H., Prot. Sci. 2, 1229-41

8401208

1993

Structural Basis of Amino Acid a Helix Propensity, Blaber, M., Zhang, X.-J. and Matthews, B.W., Science 260, 1637-40

8503008

1993

Synthetic Chimeras of Mouse Growth Factor-associated Glandular Kallikreins. II. Growth Factor Binding Properties, Blaber, M., Isackson, P.J., Holden, H.M. and Bradshaw, R.A., Prot. Sci. 2, 1220-8

8401207

1993

Synthetic Chimeras of Mouse Growth Factor-associated Glandular Kallikreins. I. Kinetic Properties, Blaber, M., Isackson, P.J., Burnier, J.P., Marsters, J.C.Jr. and Bradshaw, R.A., Prot. Sci. 2, 1210-9, Cover article

8401206

1992

Response of a Protein Structure to Cavity-Creating Mutations and Its Relation to the Hydrophobic Effect, Eriksson, A.E., Baase, W.A., Zhang, X.-J., Heinz, D.W., Blaber, M., Baldwin, E.P. and Matthews, B.W., Science 255, 178-83

1553543

1992

Dissection of Protein Structure and Folding by Directed Mutagenesis, Baase, W.A., Eriksson, A.E., Zhang, X.-J., Heinz, D.W., Sauer, U., Blaber, M., Baldwin, E.P., Wozniak, J.A. and Matthews, B.W., Faraday Discuss. 93, 173-81

1290931

1990

Structure and Function Analyses of Growth Factor Associating Murine Glandular Kallikreins, Blaber, M. Ph.D. Thesis, University of California, Irvine

 

1990

The Protease Inhibitory Properties of the Alzheimer's Beta-Amyloid Precursor Protein, Sinha, S., Dovey, H.F., Seubert, P., Ward, P.J., Blacher, R.W., Blaber, M., Bradshaw, R.A., Arici, M., Mobley, W.C. and Lieberburg, I., J. Biol. Chem. 265, 8983-5

2111813

1990

The Characterization of Recombinant Mouse Glandular Kallikreins from E. coli, Blaber, M., Isackson, P.J. and Bradshaw, R.A., Proteins: Struct. Funct. Genet. 7, 280-90

2194219

1990

Neurotrophic Factors in the CNS: Biosynthetic Processing and Functional Responses, Bradshaw, R.A., Altin, J.G., Blaber, M., Cavanaugh, K.P., Eveleth, D.D., Kornblum, H.I., Leslie, F.M. and Raffioni, S., Prog. Brain Res. 86,157-67

1965051

1989

Substrate Specificities of Growth Factor Associated Kallikreins of the Mouse Submandibular Gland, Blaber, M., Isackson, P.J., Marsters, J.C. Jr., Burnier, J.P. and Bradshaw, R.A., Biochemistry 28, 7813-9

2611215

1987

A Complete cDNA for the Major Epidermal Growth Factor Binding Protein in the Male Mouse Submandibular Gland, Blaber, M., Isackson, P.J. and Bradshaw, R.A., Biochemistry 26, 6742-9

3322386

1987

Complete Nucleotide Sequence of the Escherichia coli Gene Encoding Malate Dehydrogenase, McAlister-Henn, L., Blaber, M., Bradshaw, R.A. and Nisco, S.J., Nucl. Acids Res. 15, 4993

3299262

1987

Epidermal Growth Factor Binding Protein: Identification of a Different Protein, Isackson, P.J., Silverman, R.E., Blaber, M., Server, A.C., Nichols, R.A., Shooter, E.M. and Bradshaw, R.A., Biochemistry 26, 2082-5

3304419

1986

Purification and Characterization of Single-Chain Urokinase from E. coli, Winkler, M.E. and Blaber, M., Biochemistry 25, 4041-5

3527262

1986

Activation of Plasminogen by Pro-Urokinase. I. Mechanism, Lijnen, H.R., Zamarron, C., Blaber, M., Winkler, M.E. and Collen, D. J. Biol. Chem. 261, 1253-8

2935528

1985

Purification and Characterization of Recombinant Urokinase from E. coli, Winkler, M.E., Blaber, M., Bennet, G.L., Holmes, W.E. and Vehar, G.A., Nature Biotechnology 3, 990-1000 doi:10.1038/nbt1185-990

 

1985

Cloning and Expression of the Gene for Pro-Urokinase in Escherichia Coli, Holmes, W.E., Pennica, D., Blaber, M., Rey, M.W., Gunzler, W.A., Steffens, G.J. and Heyneker, H.L. Nature Biotechnology 3, 923-9 doi:10.1038/nbt1085-923

 

1984

Biological and Thrombolytic Properties of Proenzyme and Active Forms of Urokinase III: Thrombolytic Properties of Natural and Recombinant Urokinase in Rabbits with Experimental Jugular Vein Thrombosis, Collen, D., Stassen, J.M., Blaber, M., Winkler, M.E. and Verstraete, M., Thromb. Haemostasis 52, 27-30

6541817

Book Chapters/Other Publications

Date

Publication

2022

Protein Symmetry, Function and Stability, Blaber, M., Encyclopedia of Cell Biology, 2nd Edition (R.A. Bradshaw and P.D.Stahl, Eds.) Academic Press (Oxford)

2022

Folding, Misfolding, Disordered Proteins, and Related Diseases, Longo, L.M. and Blaber, M., Encyclopedia of Cell Biology, 2nd Edition (R.A. Bradshaw and P.D.Stahl, Eds.) Academic Press (Oxford)

2017

New Hope for the Effective Treatment of Type 2 Diabetes, Blaber, M., PLAID Journal, 2(2), 62-65

2016

Create a Custom Sky Glow Flat, Blaber, M., Amateur Astronomy 90, 48-9

2015

Folding, Misfolding, Disordered Proteins, and Related Diseases, Longo, L.M. and Blaber, M., Encyclopedia of Cell Biology, (R.A. Bradshaw and P.D.Stahl, Eds.) Academic Press (Oxford), pp. 108-14 ISBN :9780123944474

2014

Correct Translation, Rotation and Skew Adjustment of the Newtonian Secondary by Combining Laser Collimation with Flat Field Vignetting, Blaber, M., Amateur Astronomy 84, 49-50

2013

Kallikrein-related Peptidase 6, Scarisbrick, I.A. and Blaber, M., Handbook of Proteolytic Enzymes (N.D. Rawlings and G.S. Salvesen, Eds.) Academic Press (Oxford), pp. 2778-88

2011

As the Worm Turns: One Man’s Descent into Periodic Error, Blaber, M., Amateur Astronomy 71, 41-4

2005

Solvent Structure in the Active Site of Human Kallikrein 1, Laxmikanthan, G., Blaber, S.I., Scarisbrick, I.A. and Blaber, M., Hydrogen- and Hydration-Sensitive Structural Biology (N. Niimura, H. Mizuno, J. Helliwell and E. Westhof, Eds.) Kubapro, Co. Ltd Publishers (Tokyo), Ch. 3-6, 175-83

2003

The Role of the Turn Symmetry in the Folding and Stability of FGF-1, Lee, J., Kim, J., Blaber, M. and Logan, T., National High Magnetic Field Laboratory Reports 10, 11-3

2003

Myelencephalon-specific Protease, Scarisbrick, I.A., Blaber, S. and Blaber, M., Handbook of Proteolytic Enzymes, 2nd Ed., (A.J. Barrett, N.D.Rawlings and J.F. Woessner, Eds.) Elsevier Ltd. (London), Vol 1-2, pp1587-90

2000

Protein Thermal Characterization and Parameter Analysis: A Rapid, Flexible Analysis on the Windows Platform, Grek, S., Davis, J.K., and Blaber, M., Thirty-Second Southeastern Symposium on System Theory Proceedings (R.G. Roberts and F.O.Simons Jr., Eds.) pp. 41-5

1998

Denaturation Studies of Human Acidic Fibroblast Growth Factor, Adamek, D., Popovic, A., Blaber, S. and Blaber, M, Biocalorimetry: Applications of Calorimetry in the Biological Sciences (J.E. Ladbury and I. Haq, Eds.), John Wiley & Sons (New York), Chapter 16, pp. 235-41

1998

Contribution of Free Cysteine Residues to the Stability of Human Acidic Fibroblast Growth Factor, Popovic, A., Adamek, D., Blaber, S. and Blaber, M., Biocalorimetry: Applications of Calorimetry in the Biological Sciences (J.E. Ladbury and I. Haq, Eds.), John Wiley & Sons (New York), Chapter 20, pp. 277-82

1997

Biophysical and Structural Analysis of Human Acidic Fibroblast Growth Factor, Blaber, M., Adamek, D.H., Popovic, A. and Blaber, S.I., Techniques in Protein Chemistry VIII (D.R. Marshak, Ed.), Academic Press (Cambridge), 745-53

1991

Glandular Kallikreins as Growth Factor Processing Enzymes, Blaber, M., Isackson, P.J. and Bradshaw, R.A., Growth Regulation and Carcinogenesis, Vol II (W.R. Paukovits, Ed.), CRC Press, Inc. (Boca Raton)

1989

Purification of the Nerve Growth Factor Receptor, Blaber, M., Eveleth, D.D. and Bradshaw, R.A., Nerve Growth Factors, Vol 12, IBRO Handbook Series: Methods in the Neurosciences (R.A. Rush, Ed.) Cell Press (Cambridge), pp.279-98

1988

Neurotrophic Factors of the Central Nervous System: Synthesis and Activities, Bradshaw, R.A., Blaber, M., Cavanaugh, K., Eveleth, D.D., Isackson, P.J., Kornblum, H.I. Leslie, F., Morrison R.S, Schwarz, M. and Sharma, A., Symposia In Neuroscience, Volume 7: Neuronal Plasticity and Trophic Factors (G. Biggio, P.F. Spano, G. Toffano, S.H. Appel and G.L. Gessa, Eds.) Springer Verlag/Liviana Press (New York)

1987

Epidermal Growth Factor Binding Protein: A Model Serine Protease for Enzyme Engineering, Blaber, M., Blevins, R.A., Thomas, K.A., Isackson, P.J. and Bradshaw, R.A., Protein Structure, Folding and Design 2.(D. Oxender, Ed.) Alan R. Liss, Inc., (New York)

Abstracts

Date

Publication

2020

X-ray structural study on polyketide synthase involved in olivetolic acid biosynthesis in Cannabis sativa, Kono, F., Chiho, T., Blaber, M., Kuroki, R., Morimoto, S. and Tamada, T., 2020 World Conference on Protein Science, Sapporo Japan

2019

Incorporating a Functional Mutation into a Symmetric Scaffold as Proxy for Functional Adaptation via Rearrangement of its Folding Nucleus, Tenorio, C.A., Parker, J.B. and Blaber, M., 71st Japan Society for Cell Biology & 19th Protein Society of Japan meeting, Kobe Japan 2019

2019

Dermal wound healing and therapeutic intervention, Cohen, H. and Blaber, M., FSU 19th Annual Undergraduate Research Symposium

2018

FGF-1 as a therapeutic intervention for chronic wound care in aging patients, Mellers, A., Powell, B., Lacatusu, D., Patel, B., Tenorio C., Cogan, N., Harper, K.M. and Blaber, M., FSU College of Medicine Research Fair

2018

Incorporating a Functional Mutation into a Symmetric Scaffold as Proxy for Functional Adaptation via Rearrangement of its Folding Nucleus, Tenorio, C.A., Parker, J.B. and Blaber, M., FSU College of Medicine Research Fair

2017

Accelerating Healing of Dermal Wounds in the Aged, Patel, B., Mellers, A., Powell, B., Harper, K.M., Cogan, N. and Blaber, M., FSU College of Medicine Summer Research Fair

2017

Incorporating a Functional Mutation into a Symmetric Scaffold as Proxy for Functional Adaptation via Rearrangement of its Folding Nucleus, Tenorio, C.A., Parker, J.B., and Blaber, M. 31st Annual Protein Society Meeting (Protein Science, in press)

2016

Engineered FGF-1s as Therapeutics for Ocular Vesicant Injury, Eveleth, D., Gordon, E., Subramaniam, A., Hahn, R., Bradshaw, R., and Blaber, M., Soc. Toxicol. Annual Meeting

2016

Engineered FGF-1 Derivatives Lacking Cysteine for Treating Corneal Endothelial Dystrophy, Eveleth, D., Bradshaw, R.A. and Blaber, M., The FASEB Journal, 30, Suppl. 842.7

2016

Stimulation of Corneal Endothelial Proliferation and Regeneration by Engineered FGF-1, Eveleth, D., Subramaniam, A., Bradshaw, R. and Blaber, M., Gordon Research Conference on Fibroblast Growth Factors

2016

Accelerated Healing of Corneal Endothelial Lesions Induced by Engineered FGF-1 Derivatives, Bradshaw, R.,  Blaber, M., Subramanian, A., Ornitz , D. and Eveleth, D., Annual meeting of the Association for Research in Vision and Ophthalmology (ARVO)

2015

A Single Aromatic Core Mutation Converts a Designed ‘Primitive’ Protein from Halophile to Mesophile Folding, Longo, L.M., Tenorio, C.A., Kumru, O.S., Middaugh, C.R., Blaber, M., The 29th Annual Symposium of The Protein Society, Barcelona, Spain

2015

Mutation Choice to Eliminate Buried Free Cysteines in Protein Therapeutics, Xia, X., Eveleth, D. and Blaber, M., IBC 10th Annual Meeting of Next Generation Protein Therapeutics

2015

Engineered FGF-1 Derivatives Stimulate Proliferation Of Corneal Endothelial Cells, Eveleth, D.,  Xia, X., Thomas, K. and Blaber, M., 1169-D0071, Investigative Ophthalmology & Visual Science 56, 1169

2014

Efficient Protein Design by Folding Nucleus Symmetric Expansion (FNSE), Longo, L.M., Kumru, O.S., Middaugh, C.R., Blaber, M., Biopolymers Gordon Research Conference

2014

Accelerated Dermal Healing by FGF-1 in the NONcNZO10/LtJ Diabetic Mouse, Blaber, S.I., Babcock, J.P. and Blaber, M., Fibroblast Growth Factors in Development & Disease Gordon Research Conference

2013

Engineering Human Fibroblast Growth Factor-1 (FGF-1) as Regenerative Medicine, Xia, X., Lee, J. and Blaber, M., 4th  Annual Life Sciences Symposium, FSU

2013

Efficient Protein Design by Folding Nucleus Symmetric Expansion, Longo, L., Kumru, O.S., Middaugh, C.R. and Blaber, M. 4th  Annual Life Sciences Symposium Florida State University, 2nd Place Poster Award

2013

Kallikrein 6 Promotes Neurotoxicity by Activating Protease Activated Receptors, Yoon, H., Radulovic, M., Wu, J., Blaber, S.I., Blaber, M., Fehlings, M.G., Scarisbrick, I.A., 5th International Symposium on Kallikreins and Kallikrein Related Peptidases, Third Place Platform Presentation Award

2013

Kallikrein 6 Mediates Therapy Resistance in Glioblastoma, Drucker, K.L, Paulsen, A.R, Giannini, C., Decker, P.A., Blaber, S.I., Blaber, M., Jenkins,R.B. and Scarisbrick, I.A., 5th International Symposium on Kallikreins and Kallikrein-Related Peptidases, First Place Poster Award

2013

Structural Characteristics of Halophilic Proteins Investigated by X-Ray Crystallography, Arai, S., Ishibashi, M., Yonezawa, Y., Adachi, M., Tamada, T., Tokunaga, H., Tokunaga, M., Blaber, M. and Kuroki, R., 7th Intl. Conf. Struct. Genomics

2013

Kallikrein 6 signals Through PAR1 and PAR2 to Promote Neurotoxicity and Exacerbate Glutamate-Mediated Excitotoxicity, Yoon, H., Radulovic, M., Wu, J., Blaber, S.I., Blaber, M., Fehlings, M.G. and Scarisbrick, I.A.,  FASEB J., 27, p. 662.20

2013

Engineering Human Fibroblast Growth Factor (FGF-1) as Regenerative Medicine, Xia, X. and Blaber, M., 3rd  Annual Life Sciences Symposium Florida State University

2013

How Protein Engineering can Afford a Rare Glimpse at the Origin of Life / Simplified Protein Design Biased for Pre-Biotic Amino Acids Yields a Foldable, Halophilic Protein, Longo, L.M., Lee, J. and Blaber, M., 3rd  Annual Life Sciences Symposium Florida State University

2012

Changes in Kallikrein 6-Related Peptidase in Severe, Moderate, and Mild Models of Traumatic Brain Injury, Phipps, H., Suber, J.F., Marin, V., Blaber, S.I., Blaber, M. and VanLandingham, J.W., National Neurotrauma Symposium, C54

2012

Solid-State NMR Structural Analysis of Syfoil-1: A Controllable Amyloid-Forming Protein, Longo, L., Lee, J. Blaber, M. and Paravastu, A., 53rd Experimental Nuclear Magnetic Resonance Conference p. 99

2012

Novel Saloplastic Wound Dressing Technology for Accelerated Healing, Xia, X., Blaber, M. and Schlenoff, J., 2nd Annual Life Sciences Symposium Florida State University

2012

Folding Pathway Redundancy and the Evolution of Symmetric Protein Architecture, Longo, L., Lee, J. and Blaber, M., 2nd Annual Life Sciences Symposium Florida State University

2011

The Rise and Fall of Kallikrein 6 in Traumatic Brain Injury, Phipps, H. W., Jackson, S., Suber, J., Levenson, C.W., Blaber, S.I., Blaber, M. and Vanlandingham, J., J. Head Trauma Rehab. 26, 426

2011

Immunopathophysiological Roles of Kallikreins in CNS Inflammatory Disease, Scarisbrick, I.A., Renner, D.N., Blaber, S., Blaber, M., Yoon, H., Vandell, A.G. and Paulsen, A.R., 4th International Symposium on Kallikreins and Kallikrein-related Peptidases, p.31

2011

Functional Intersection of Matrix Metalloproteases with Kallikrein-Related Peptidases, Blaber, M., Blaber, S., Yoon, H. and Scarisbrick, I.A., 4th International Symposium on Kallikreins and Kallikrein-related Peptidases, p.27

2011

Role of Kallikrein-Related Peptidase 6 in Atrogliosis, Radulovic, M., Burda, J. Drucker, K., Blaber, S., Blaber, M., Yoon, H., Vandell, A.G., Paulsen, A.R. and Scarisbrick, I.A., 4th International Symposium on Kallikreins and Kallikrein-related Peptidases, p.69

2011

Human Pro-KLK4 Activation, Revisited, Blaber, S., Li, W., Yoon, H., Scarisbrick, I.A., and Blaber, M., 4th International Symposium on Kallikreins and Kallikrein-related Peptidases, p. 83

2011

An Empirical Phase Diagram Approach to Investigate Conformational Stability of “Second-generation” Functional Mutants of Acidic Fibroblast Growth Factor, Alsenaidy, M.A., Wang, T., Lee, J. Blaber, M., Kim, J.H., Joshi, S., Volkin, D.B. and Middaugh, C.R., Colorado Protein Stability Conference

2011

Turn Structure in the Transition State of Fibroblast Growth Factor-1, Longo, L., Lee, J., Lee, W. and Blaber, M., 1st Annual Life Sciences Symposium Florida State University

2011

Identification of rK6 Inhibitor in Rat Brain, Jackson, S. and Blaber, M., 1st Annual Life Sciences Symposium Florida State University

2010

The Interaction between Thermodynamic Stability and Buried Free Cysteines in Regulating the Functional Half-Life of Fibroblast Growth Factor-1, Lee, J. and Blaber, M., Zing Structural Biology and Drug Discovery Conference

2009

Salt and Glycosaminoglycan Effects on Substrate Specificity of Human Kallikrein 3 (hKLK3) and 13 (hKLK13), Andrade, d., Lima, A.R., Assis, D.M., Angelo, P.F., Alves, F.M., Blaber, S.I., Blaber, M., Juliano, M.A. and Juliano, L., 3rd International Symposium on Kallikreins & Kallikrein-related Peptidases, p. 47

2009

Regulation and Function of Kallikrein Related Peptidase 6 in Malignant Melanomas, Krenzer S., Klucky B., Mauch C., Blaber M., Angel P., and Hess J., 3rd International Symposium on Kallikreins & Kallikrein-related Peptidases, p. 37

2009

Structural Biology and Enzymology of the Human Kallikrein-Related Peptidases, Blaber, M., Yoon, H., Lee, J., Scarisbrick, I.A., Debela, M., Goettig, P. and Blaber, S., 3rd International Symposium on Kallikreins & Kallikrein-related Peptidases, p. 25

2009

Kallikrein Mediated Signaling in CNS Neurons and Astrocytes, A. G. Vandell, J. E. Burda, N. Larson, J. Wu, P. Angelo, S. I. Blaber, M. Blaber and Scarisbrick, I. A., Society for Neuroscience Annual Meeting

2008

Association of Kallikreins with Neuron Loss and Progressive Multiple Sclerosis, Linbo, R.A., Vandell, A.G., Larson, N.S., Keegan, M.B., Blaber, S.I., Blaber, M., Sneve, D.M., Lucchinetti, C.F., Rodriguez, M., Diamandis, E.P. and Scarisbrick, I.A., 133rd American Neurological Association Meeting

2008

A Logical OR Redundancy within the Asx-Pro-Asx-Gly Type I b-turn Motif, Lee, J., Dubey, V., Longo, L., and Blaber, M., Protein Science, 17 (suppl. 1), 232

2008

The Autolytic Regulation of Human Kallikrein-Related Peptidase 6 is Negative Feedback Inhibition, Blaber, S., Yoon, H., Scarisbrick, I., Juliano, M., and Blaber, M., Protein Science, 17 (suppl. 1), 97

2008

Activation Profiles and Regulatory Cascades of the Human Kallikrein-Related Peptidases, Yoon, H., Laxmikanthan, G., Lee, J., Blaber, S., Rodriguez, A., Kogot, J. and Blaber, M., Protein Science, 17(suppl. 1), 96

2008

De Novo Protein Design Technique in Cardiovascular Heart Disease: Expanding to a Systematic Approach, Smith, A., Russo, C., Nymeyer, H., Blaber, M. and Fenley, M.O., FLACS LXI, 84

2007

The Autolytic Regulation of Human Kallikrein-Related Peptidase 6 is Negative Feedback Inhibition, Blaber, S.I., Yoon, H., Scarisbrick, I.A., Juliano, M.A., and Blaber, M. 2nd International Symposium on Kallikreins & Kallikrein-related Peptidases, 57

2007

The First Screening Method to Identify Potential Activation for the Human Kallikrein Family, Yoon, H., Laxmikanthan, G., Lee, J., Blaber, S.I., Rodriguez, A., Kogot, J.M., Scarisbrick, I.A., and Blaber, M., 2nd International Symposium on Kallikreins & Kallikrein-related Peptidases, 54

2006

Multiple Human Tissue Kallikreins are Regulated by Lympho-Epithelial Kazal-Type Inhibitor and Digest Desmoglein 1, Borgono, C. A., Michael, I. P., Komatsu, N., Sotiropoulou, G., Jayakumar, A., Wu, H., Clayman, G. L., Blaber, S. I., Blaber, M., Mikolajczyk, S. D. and Diamandis, E. P., Journal Of Investigative Dermatology 126, 60

2005

1.70Å X-ray Structure of Human Apo Kallikrein 1: Structural Changes upon Peptide Inhibitor/Substrate Binding, Laxmikanthan, G., Blaber, S.I., Bernett, M.J., Scarisbrick, I.A., Juliano, M.A. and Blaber, M., 1st International Symposium on Kallikreins, 45

2005

Kallikreins and Cell Signaling: Differential Regulation of Proteinase-Activated Receptors (PARS), Oikonomopoulou, K., Hansen, K.K., Saifeddine, M., Vergnolle, N., Tea, I., Blaber, M., Blaber, S.I., Scarisbrick, I., Diamandis, E.P., and Hollenberg, M.D., 1st International Symposium on Kallikreins, 53

2005

Hydrogen and Hydration DataBase for Bio-Macromolecules (HHDB), Kuroki, R., Chatake, T., Kurihara, K., Ohhara, T., Umino, H., Cachau, R.E., Blaber, M. and Niimura, N. Acta cryst. A61, C481

2005

Redesigning the "Mini-Core" Regions of FGF-1 to Increase Primary Structure Symmetry, Dubey, V.K. and Blaber, M. Prot. Sci. 14 (suppl. 1),175

2005

A novel method to characterize the activation of serine proteases using hybrid bait protein, Laxmikanthan, G., Kogot, J., Blaber, S.I. and Blaber, M. Prot. Sci. 14(suppl. 1),167

2005

Effect of Beta-Hairpin Conformations on Protein Stability and Folding Kinetics, Lee, J. and Blaber, M. Prot. Sci. 14(suppl. 1),106

2004

Tissue-Specific Expression and Differential Regulation of Multiple Kallikrein 6 Transcripts in CNS Demyelinating Disease, Christophi, G.P., Isackson, P.J., Blaber, S.I., Blaber, M., Rodriguez, M. and Scarisbrick, I.A., 36th Annual Soc. Neurosci. 936,12

2004

1.7Å X-Ray Structure of Apo Human Kallikrein 1: Evidence for an Induced-Fit Basis of Dual Substrate Specificity, Laxmikanthan, G., Blaber, S.I., Bernett, M.J., Scarisbrick, I.A., Juliano, M.A. and Blaber, M., Gordon Research Conference on Proteolytic Enzymes and Their Inhibitors

2004

Protein Symmetry, Stability and Function, Dubey, V.K., Brych, S.R., Lee, J. and Blaber, M, 59th Annual CALCON Calorimetry Conference, p. 27

2003

Structure, Stability and Functional Studies of 2,5-Diketo-D-Gluconate Reductases, Blaber, M., Dudley, J. and Sanli, G., American Heart Association Research Symposium, p. 5

2003

Structural Symmetry in a b-Trefoil Superfold , Brych, S.R., Kim, J., Logan, T.M. and Blaber, M., New Horizons in Molecular Sciences and Systems: An Integrated Approach, Okinawa Institute of Science and Technology Project, Cabinet Office, The Government of Japan

2003

Increased Primary Sequence Symmetry within the Hydrophobic Core of hFGF-1: Evidence of Genetic Drift, Brych, S.R., Kim, J., Logan, T.M. and Blaber, M., FLACS LVI, p.20

2003

Cloning of the Human Kallikreins, Frost, N.A., Blaber, S.I., and Blaber, M., FLACS LVI, p.19

2003

Expanded Substrate Specificity of Human Kallikrein 6 (hK6), Bernett, M.J., Blaber, S.I., Somasundaram, T. and Blaber, M., FLACS LVI, p.18

2003

Thermal Stability of Various Disulfide Bond Mutants of 2,5-DKGR-A, Dudley, J.I. and Blaber, M., FLACS LVI, p.18

2003

Effect of Turn Conformational Change on Protein Folding Kinetics in Human Acidic Fibroblast Growth Factor 1(hFGF-1), Lee, J., Kim, J. and Blaber, M., FLACS LVI, p.18

2003

Identification of a Key Structural Element for Protein Folding within b-Hairpin Turns, Kim, J., Brych, S.R., Lee, J., Logan, T.M. and Blaber, M., FLACS LVI, p.18

2003

Molecular Insights on Substrate Specificity of Human Kallikrein 1, Laxmikanthan, G., Blaber, S., Bernett, M. and Blaber, M., FLACS LVI, p.17

2003

Cofactor Specificity of Corynebacterium 2,5-Diketo-D-Gluconic Acid Reductase for NADP(H), Sanli, G. and Blaber, M., FLACS LVI, p.16

2002

Metabolic and Protein Engineering in the Development of a New Method for the Production of Vitamin C, Sanli, G., Dudley, J.I. and Blaber, M., Program of the Southeastern Branch of the American Society for Microbiology A47

2002

Structure and Stability Effects of Mutations Designed to Increase the Primary Sequence Symmetry within the Core Region of a b-trefoil, Brych, S., Blaber, S., Logan, M. and Blaber, M., Protein Science 11 (suppl. 1), 218

2002

Crystal Structure and Biochemical Characterization of Human Kallikrein 6 Reveals a Trypsin-Like Kallikrein is Expressed in the Central Nervous System, Bernett, M.J., Blaber, S.I., Scarisbrick, I.A., Dhanarajan, P., Thompson, S.M. and Blaber, M., Protein Science 11 (suppl. 1), 137

2002

Alternative Type I and I' Turn Conformations in the b8/b9 b-Hairpin of Human Acidic Fibroblast Growth Factor, Kim, J., Blaber, S.I. and Blaber, M., Protein Science 11 (suppl. 1), 80

2002

Enzymatic Properties of Rat Myelencephalon-Specific Protease, Blaber, S., Scarisbrick, I., Dhanarajan, P., Bernett, M., Schwartz, M., Seavy, M., Rodriguez, M., Jin, Y. and Blaber, M., Protein Science 11 (suppl. 1), 59

2002

Crystal Structure and Biochemical Characterization of Human Kallikrein 6 Reveals a Trypsin-Like Kallikrein is Expressed in the Central Nervous System, Bernett, M.J., Blaber, S.I., Scarisbrick, I.A., Dhanarajan, P., Thompson, S.M. and Blaber , M. Gordon Research Conference on Proteolytic Enzymes and Their Inhibitors

2002

Crystal Packing Effects upon Protein Structure Determined by X-Ray Crystallography, Blaber, M., Kim, J. and Blaber, S., Abstracts of Papers of the American Chemical Society 223, 166-IEC Part 1

2002

Role of a Newly Identified Serine Protease in Immune-Mediated Demyelination, Scarisbrick I.A., Blaber S.I., Blaber M. and Rodriguez M., FASEB Journal 16, A591-A591 Part 1

2001

Stability and Dynamics Issues in Enzyme Engineering of an Aldo-keto Reductase, Sanili, G. and Blaber, M. SERMACS 2001, 121

2001

Alterations in Structure, Stability and Folding Kinetics Associated with an Increase in Internal Symmetry in Human Fibroblast Growth Factor 1, Brych, S., Blaber, S.I., and Blaber, M. Protein Science 10 (suppl. 2), 182

2001

Expression, Purification and in vitro Characterization of Myelencephalon Specific Protease (MSP), a Novel Serine Protease Expressed in Mammalian Central Nerve System, Blaber, S.I., Dhanarajan, P., Scarisbrick, I.A., Seavy, M., Jin, Y. and Blaber, M. Protein Science 10 (suppl. 2), 161

2001

Alternate Conformations in the beta 8/beta 9 Loop of Human Fibroblast Growth Factor 1, Kim, J., Blaber, S.I., Brych, S. and Blaber, M. Protein Science 10 (suppl. 2), 74

2001

The Role of Symmetry in Protein Folding and Design, Blaber, M., Brych, S. and Kim, J. FLACS 54, 19

2001

Expression, Purification and in vitro Characterization of Myelencephalon Specific Protease (MSP), A Novel Serine Protease Expressed in Mammalian Central Nerve System, Blaber, S., Bernett, M.J., Dhanarajan, P., Scarisbrick, I.A., Seavy, M., Jin, Y. and Blaber, M., Southeast Nerve Net, 17th Annual Meeting

2001

X-ray Structure of Apo-2,5-Diketo-D-Gluconic Acid Reductase A, Sanli, G., Somasundaram, T. and Blaber, M., Biophysical Journal 80, 257 Part 2

2000

Energetics of the Myosin IISH1 Helix During Contractility, Sale, K., Kelly, D.F., Fajer, P. and Blaber, M., Biophysical Journal 78, 1448

2000

Structural Studies of Synthetic 2,5-Diketo-D-gluconic Acid Reductase Complexed with its Substrate and Oxidized Cofactor, Sanli, G. and Blaber, M. Proc. 8th Intl. Conf. Crystal. Biol. Macromol., 202

2000

Structural Biology of the Mouse Glandular Kallikrein Family of Proteases, Kim, J., Blaber, S.I. and Blaber, M., Proc. 8th Intl. Conf. Crystal. Biol. Macromol., 165

2000

A His-tagged form of Human Acidic Fibroblast Growth Factor with Enhanced Crystallographic Properties, Blaber, S.I. and Blaber, M., Proc. 8th Intl. Conf. Crystal. Biol. Macromol., 121

2000

Structural Changes Associated with Mutations Designed to Probe the Role of a Symmetric Core-packing Arrangement in Human Acidic FGF, Brych, S.R., Blaber, S., Khurana, A. and Blaber, M., Proc. 8th Intl. Conf. Crystal. Biol. Macromol., 102

2000

A Rapid Accurate and Automated Windows-based Program for the Analysis of Differential Scanning Calorimetry Data, Grek, S., Davis, J. and Blaber, M. Protein Science 9 (Suppl.1) 167

2000

The Role of Post-translational Modification on the Enzyme Activity of Mouse Glandular Kallikreins, Kim, J., Blaber, S.I., and Blaber, M. Protein Science 9 (Suppl.1) 110

2000

Structure and Stability Effects of Cavity Reducing and Core Packing Mutants in Human Fibroblast Growth Factor I, Brych, S.R., Blaber, S.I., Khurana, S. and Blaber, M. Protein Science 9 (Suppl.1) 108

2000

The Effects of Cysteine Mutations on the Stability of Human Acidic FGF, Culajay, J.F., Blaber, S.I., Khurana, A. and Blaber, M. Protein Science 9 (Suppl.1) 100

2000

Increased Stability of Human FGF-1 Against Thermal Denaturation by Sulfate and Phosphate Binding, Whitten, S.T., Blaber, S.I., and Blaber, M., Protein Science 9 (Suppl.1) 94

2000

A Flexible, 2-State, Statistical Mechanics Based Model For DSC Analysis Implemented Under Windows, Grek, S., Davis, J. and Blaber, M. Proceedings of the Gibbs Symposium

2000

Reversible Thermal Denaturation of Human FGF-1 Induced by Low Concentrations of Guanidine HCl, Blaber, S. I., Culajay, J.F., Khurana, A. and Blaber, M., Proceedings of the Gibbs Symposium

1999

Deconvolution of Calorimetric Data for the Characterization of Protein Thermodynamic Parameters, Grek, S., Davis, J., Noble, N. and Blaber, M. Proceedings of the 54th Calorimetry Conference, 154

1999

Structure and Stability Effects of Mutations Designed to Probe the Role of a Symmetric Core-packing Arrangement in Human Acidic FGF, Brych, S.R., Blaber, S., Khurana, S., Khurana, A. and Blaber, M. Proceedings of the 54th Calorimetry Conference, 147

1999

Thermodynamic Characterization of Mutants of Human FGF-1 that have an Increased Physiological Half-life, Culajay, J.F., Blaber, S.I., Khurana, S., Khurana, A., Kennedy, D., Williams, K. and Blaber, M. Proceedings of the 54th Calorimetry Conference, 150

1999

Construction and Characterization of a Synthetic 2,5-Diketo-D-Gluconate Reductase Gene, Sanli, G., Blaber, S., Khurana, S. and Blaber, M. Proceedings of the 54th Calorimetry Conference, 164

1999

Energetics of the Myosin II SH1 Helix during Contractility, Kelly, D., Sale, K. and Blaber, M. Proceedings of the 54th Calorimetry Conference, 158

1999

Structural Characterization of a Highly Thermostable Mutant of Human Acidic Fibroblast Growth Factor (FGF-1), Khurana, S., Culajay, J.F., Grek, S., Khurana, A. and Blaber, M., Protein Science 8, 125

1999

Thermodynamic Characterization of Mutants of Human FGF-1 that have an Increased Physiological Half-life, Culajay, J.F., Blaber, S.I., Khurana, S., Khurana, A., Kennedy, D. and Blaber, M. Protein Science 8, 95

1999

The Role of Low Concentrations of Guanidine HCl in Reversible Thermal Denaturation of Human FGF-1, Blaber, S.I., Culajay, J.F., Khurana, A. and Blaber, M., Protein Science 8, 96

1999

Construction and Characterization of a Synthetic Gene for 2,5-Diketo-D-Gluconate Reductase, Sanli, G., Blaber, S., Khurana, S. and Blaber, M. Protein Science 8, 65

1999

The Role of Low Concentrations of Guanidine HCl in Reversible Thermal Denaturation of Human Fibroblast Growth Factor-1, Blaber, M., Blaber, S.I., Culajay, J.F., and Khurana, A. FLACS 52, 10

1999

Proton Donor Promiscuity in an Aldo-keto Reductase, Khurana, S., Sanli, G., Powers, D.B., Anderson, S. and Blaber, M. FLACS 52, 49

1999

Construction and Characterization of a Synthetic Gene for 2,5-Diketo-D-Gluconate Reductase, Sanli, G., Blaber, S., Khurana, S. and Blaber, M. FLACS 52, 49

1999

The Role of Low Concentrations of Guanidine HCl in Reversible Denaturation of Human Acidic Fibroblast Growth Factor-1, Blaber, S.I., Culajay, J.F., Khurana, A. and Blaber, M. Biophysical Journal, 76, A107

1998

Deconvolution of Calorimetric Data for Protein Stability Studies, Grek, S., Davis, J. and Blaber, M. Proceedings of the 1st Annual NASA Partners in Education and Research Conference

1998

Crystal Structure of 2,5-diketo-D-Gluconic Acid Reductase A Complexed with NADPH at 2.1Resolution, Khurana, S., Powers, D.B., Anderson, S. and Blaber, M. Protein Science 7 (suppl. 1) 122

1998

Cysteine Residue Mutations in Human Acidic FGF and Effects upon Thermal Stability, Culajay, J.F., Blaber, S.I. and Blaber, M. FLACS 51, 44

1998

Structural Influence on Specificity and Catalytic Behavior in Serine Proteases, Badisa, R.B., Blaber, S.I. and Blaber, M. FLACS 51, 44

1998

Evaluation and Characterization of Mutations of Human Acidic Fibroblast Growth Factor to Enhance Thermal Stability and Biological Activity, Grek, S., Culajay, J.F. and Blaber, M., 21st Annual Research Seminar, American Cancer Society

1998

Effects of Low Concentrations of Guanidine Hydrochloride on the Stability and Reversible Denaturation of Human Acidic Fibroblast Growth Factor, Blaber, S. and Blaber, M., Proceedings of the 3rd Annual Johns Hopkins Protein Folding Meeting

1997

Structure Solved for Key Enzyme in Vitamin C Production, Blaber, M., Industrial Bioprocessing 19, 5

1997

Modulation of Protein Stability, Blaber, M. FLACS 50, 33

1997

The Preliminary X-Ray Characterization and Molecular Replacement Studies with 2,5-Diketo-D-Gluconate Reductase Crystals, Khurana, S., Powers, D. and Blaber, M. FLACS 50, 39

1997

An Approach to Accurate DSC Analyses of Irreversibly Unfolding Proteins, Adamek, D., Blaber, S., Culajay, J.F. and Blaber, M., FLACS 50, 59

1997

Contribution of the Cysteine Residues to the Thermal and Physiological Stability of the Human Acidic Fibroblast Growth Factor, Culajay, J.F., Blaber, S., Adamek, D., Khurana, S. and Blaber, M. FLACS 50, 59

1997

Mechanisms of Regulation of Human Acidic Fibroblast Growth Factor, Blaber, M., Adamek, D., Blaber, S., Culjay, J. and Khurana, S., 20th Annual Research Seminar American Cancer Society, Florida Division

1997

Avoiding the Aggravation of Aggregation: Denaturation Studies of Acidic Fibroblast Growth Factor, Adamek, D., Grek, S., Blaber, S. and Blaber, M., Proceedings of the 5th Annual Suddath Symposium

1997

The Use of Low Concentration Guanidine Hydrochloride to Achieve Reversible Thermal Denaturation of Acidic Fibroblast Growth Factor, Adamek, D., Blaber, S. and Blaber, M., Proceedings of the 2nd Annual Johns Hopkins Protein Folding Meeting

1996

Denaturation Studies of Human Acidic Fibroblast Growth Factor, Adamek, D., Popovic, A., Blaber, S. and Blaber, M. First International Conference on the Applications of Biocalorimetry, R-01

1996

Contribution of Free Cysteine Residues to the Stability of Human Acidic Fibroblast Growth Factor, Popovic, A., Adamek, D., Blaber, S. and Blaber, M. First International Conference on the Applications of Biocalorimetry, P-19

1996

X-ray Crystal Structure of Human Acidic Fibroblast Growth Factor, Blaber, M., Protein Science 5 (suppl. 1), 101

1996

Crystallographic Analysis of the Central Cavity of Interleukin-1b, Blaber, M., Yu, B., Bhyravbhatla, B. and Caspar, D.L.D., International Conference on Protein Folding and Design, National Institutes of Health

1996

Structure and Function Studies of Mouse Glandular Kallikreins, Lang, E. and Blaber, M. Proceedings of the 4th Annual Suddath Symposium

1996

Stability Studies of Human Acidic Fibroblast Growth Factor. I. Effect of pH on the Enthalpy of Unfolding, Popovic, A., Adamek, D. and Blaber, M., Proceedings of the 4th Annual Suddath Symposium

1996

Stability Studies of Human Acidic Fibroblast Growth Factor. II. Effect of Denaturants on the Reversibility of Unfolding, Adamek, D., Popovic, A. and Blaber, M., Proceedings of the 4th Annual Suddath Symposium

1996

X-ray Crystal Structure of Human Acidic Fibroblast Growth Factor, Blaber, M., Proceedings of the 4th Annual Suddath Symposium

1996

Structure of Human Acidic Fibroblast Growth Factor, Blaber, M., 19th Annual Research Seminar, American Cancer Society

1996

pH Studies of Human Acidic Fibroblast Growth Factor, Adamek, D., Popovic, A. and Blaber, M., 19th Annual Research Seminar, American Cancer Society

1995

Protein Stability as a Regulatory Mechanism, Blaber, M. FLACS 48, 65

1995

Structure and Specificity Relationships in Serine Proteases, Lang, E. and Blaber, M. FLACS 48, 45

1995

Buried Cysteine Residues and Irreversible Protein Denaturation, Popovic, A. and Blaber, M. FLACS 48, 42

1994

Crystallographic Analysis of Mouse Pro-renin Converting Enzyme, Blaber, M. J. Cell. Biochem., Suppl. 18D, 151

1993

Data Collection from Crystals of Escherichia coli b-Galactosidase, Jacobson, R.H., Blaber, M., Dubose, R.F. and Matthews, B.W. Photon Factory Activity Report 11, 79

1992

Mutations Affecting Solvent Accessibility in a-Helices, Blaber, M., Baase, W.A. and Matthews, B.W. Protein Society, 6th Symposium Proceedings, 45

1992

Structural and Thermodynamic Consequences of Mutations which Introduce a Hydroxyl Group in T4 Lysozyme, Gassner, N., Blaber, M., Lindstrom, J.D. and Matthews, B.W. Protein Society, 6th Symposium Proceedings, 45

1991

Structural and Genetic Analysis of the Interactions that Stabilize Proteins, Dao-pin, S., Nicholson, H., Zhang, X.-J., Baase, W.A., Blaber, M., Heinz, D. and Matthews, B.W., J. Cell. Biochem. 15G, 46

1991

Alanine-Serine Substitutions within α-Helical Secondary Structure: Effects upon Protein Stability, Blaber, M. and Matthews, B.W., J. Cell. Biochem. 15G, 205

1991

Processing of Growth Factor Precursors, Bradshaw, R.A., Blaber, M. and Isackson, P.J., J. Cell. Biochem. 15G, 106

1990

The Kunitz Protease Inhibitory Domain of the Beta-amyloid Precursor Protein is Sufficient for its Protease Inhibitory Properties, Sinha, S., Dovey, H.F., Seubert, P., Ward, P.J., Blacher, R.W., Blaber, M., Bradshaw, R.A., Arici, M., Mobley, W.C. and Lieberburg, I., Neurobiology of Aging 11, 311

1989

Processing of Recombinant Nerve Growth Factor, Isackson, P.J., Blaber, M., Cavanaugh, K. and Bradshaw, R.A. Trophic Agents V, Society for Neuroscience Abstracts, 15, 866

1987

Epidermal Growth-Factor Binding-Protein - A Model Serine Protease for Enzyme Engineering, Blaber, M., Isackson, P.J. and Bradshaw, R.A., Journal of Cellular Biochemistry Suppl. 11C, 223

1987

Growth Factor Processing: Molecular Modelling of EGF and NGF Associated Kallikreins, Blaber, M., Blevins, R., Thomas, K.A., Isackson, P.J. and Bradshaw, R.A., Abst. 1st Symp. Protein Soc., 42

1985

Natural and Recombinant High Molecular Weight Urokinase Contain a Kringle Specific Benzamidine Binding Site, Blaber, M. and Winkler, M.E., Thromb. Haemostasis 54, 103

1984

Molecular Characterization of Human Urokinase Produced in Bacteria as Compared to Urokinase Obtained from Human Urine, Steffens, G.J., Gunzler, W.A., Henninger, W., Hennies, H.H., Kim, S.M.A., Otting, F., Frankus, E., Flohe, L., Blaber, M. and Winkler, M.E., Haemostasis 14, 60

1984

Functional Characterization of Human Urokinase Produced in Bacteria as Compared to Urokinase Obtained from Human Urine, Gunzler, W.A., Henninger, W., Hennies, H.H., Otting, G., Schneider, J., Frederichs, E., Giertz, H., Flohe, L., Blaber, M. and Winkler, M.E. Haemostasis 14, 60

1983

The Comparison of E. coli Recombinant Urokinase with Natural Urokinase, Winkler, M.E., Blaber, M. and Vehar, G.A. Thromb. Haemostasis 50, 386